Novel Simple Approach for Differentiating Concentrated or Diluted Blood Samples, Hematological Disorders and Organ Dysfunctions in Acute Care Settings-A Global Perspective

Abstract

Dilution or concentration of blood sample during patient receiving intravenous fluids or at presentation of disease with severe volume depletion is common clinical scenario. There are various gold standard advanced technological time-consuming elective methods like radioactive chromium method, radioactive iodine method, etc which are useful for diagnosis of dilution or concentration. But during routine examination especially at smaller peripheral centres or low-income countries where these facilities are lacking, it is difficult to check that either sample is diluted, concentrated or due to altered pathological diseased state as both will give modified results than the actual state of the patient’s current pathophysiological condition. In acute care trauma settings, intensive or critical care units and high dependency units with critically ill patients many of them having multiple organ dysfunction and associated co-morbidities, many of the decisions about their care will be based on the results of hematological and biochemical profile and the time is very crucial to take decision and act in immediately. The simple innovative approach described allows quick and accurate decision making based on correct interpretation of the investigative findings.