Novel silicone rubber and polyvinyl alcohol (pva) compound as nucleus pulposus replacement in intervertebral disc herniation surgery

Permana, Galih Indra; Bajamal, Abdul Hafid; Subagio, Eko Agus; Parenrengi, Muhammad Arifin; Rasyida, Amaliya; Utomo, Budi

doi:10.5137/1019-5149.jtn.35925-21.3

Cited by 2 publications

(2 citation statements)

References 19 publications

(32 reference statements)

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“…Regarding the progress of research on PVA hydrogel as an NP replacement material, Leone et al found that PVA with PVP molar ratio of 1:1 has excellent biomechanical characteristics which is a promising NP replacement material ( Leone et al, 2019 ). Permana et al reported that the biomechanical properties of PVA combined with Silicone Rubber close to human NP ( Permana et al, 2022 ).…”

Section: Hydrogel Repair Strategymentioning

confidence: 99%

Recent advances in the repair of degenerative intervertebral disc for preclinical applications

Ying,

Cai,

Cai

et al. 2023

Front. Bioeng. Biotechnol.

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The intervertebral disc (IVD) is a load-bearing, avascular tissue that cushions pressure and increases flexibility in the spine. Under the influence of obesity, injury, and reduced nutrient supply, it develops pathological changes such as fibular annulus (AF) injury, disc herniation, and inflammation, eventually leading to intervertebral disc degeneration (IDD). Lower back pain (LBP) caused by IDD is a severe chronic disorder that severely affects patients’ quality of life and has a substantial socioeconomic impact. Patients may consider surgical treatment after conservative treatment has failed. However, the broken AF cannot be repaired after surgery, and the incidence of re-protrusion and reoccurring pain is high, possibly leading to a degeneration of the adjacent vertebrae. Therefore, effective treatment strategies must be explored to repair and prevent IDD. This paper systematically reviews recent advances in repairing IVD, describes its advantages and shortcomings, and explores the future direction of repair technology.

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Section: Hydrogel Repair Strategymentioning

confidence: 99%

Recent advances in the repair of degenerative intervertebral disc for preclinical applications

Ying,

Cai,

Cai

et al. 2023

Front. Bioeng. Biotechnol.

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“…In addition, poly (vinyl alcohol) is a biodegradable material that can be improved in its degradability through hydrolysis due to the presence of hydroxyl groups on carbon atoms [ 19 , 20 ]. PVA is widely used for hydrogel [ 21 , 22 ] and has been investigated for injectable materials in nucleus pulposus replacement therapy [ 23 ]. On the other hand, graphene is a carbon atom composed of monolayers and forms 2D structures.…”

Section: Introductionmentioning

confidence: 99%

A Composite of Hydrogel Alginate/PVA/r-GO for Scaffold Applications with Enhanced Degradation and Biocompatibility Properties

et al. 2023

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We reported in this study the interrelation between the addition of 0.4, 0.8, 1.2, and 1.6 wt. % reduced graphene oxide (r-GO) into PVA/Alginate and their degradation and biocompatibility properties. The r-GO was synthesized by using the Hummer’s method. A crosslinker CaSO4 was added to prepare Alginate/PVA/r-GO Hydrogel composite. A Field Emission in Lens (FEI)-scanning electron microscopy (SEM), along with X-ray energy dispersive spectroscopy (EDS), was performed, characterizing the morphology of the composite. A compressive test was conducted, determining the mechanical properties of the composite with the highest achieved 0.0571 MPa. Furthermore, in vitro cytotoxicity was conducted to determine the biocompatibility properties of the studied composite. An MTT assay was applied to measure cell viability. In general, the presence of r-GO was found to have no significant effect on the morphology of the hydrogel. Indeed, adding 0.4% r-GO to the PVA/Alginate increased the cell viability up to 122.26 ± 0.93, indicating low toxicity. The studied composites have almost no changes in weight and shape, which proves that low degradation occurred in addition to this after 28 days of immersion in saline phosphate buffer solution. In conclusion, achieving minimal degradation and outstanding biocompatibility lead to PVA/Alginate/r-GO hydrogel composites being the most attractive materials for tissue engineering applications.

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Novel silicone rubber and polyvinyl alcohol (pva) compound as nucleus pulposus replacement in intervertebral disc herniation surgery

Cited by 2 publications

References 19 publications

Recent advances in the repair of degenerative intervertebral disc for preclinical applications

Recent advances in the repair of degenerative intervertebral disc for preclinical applications

A Composite of Hydrogel Alginate/PVA/r-GO for Scaffold Applications with Enhanced Degradation and Biocompatibility Properties

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