Novel serological biomarkers for inflammation in predicting disease severity in patients with COVID-19

Xue, Guohui; Gan, Xing; Wú, Zhìqiáng; Xie, Dan; Xiong, Yan; Hua, Lin; Zhou, Bo; Zhou, Nan; Xiang, Jie; Li, Junming

doi:10.1016/j.intimp.2020.107065

Cited by 93 publications

(137 citation statements)

References 41 publications

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“…Fifty-two studies (77.6%) were performed in China [ 22 , 24 – 26 , 28 – 31 , 33 – 35 , 37 – 43 , 46 – 57 , 59 , 62 – 64 , 68 – 85 ] while the remaining 15 were conducted in the rest of the world [ 20 , 21 , 23 , 27 , 32 , 36 , 44 , 45 , 58 , 60 , 61 , 65 – 67 , 86 ]. Endpoints included disease severity based on current clinical guidelines (31 studies, 46%) [ 22 , 24 , 28 , 32 , 33 , 35 , 36 , 38 , 39 , 44 – 47 , 49 – 52 , 54 , 56 , 58 , 64 , 66 , 69 , 72 , 73 , 75 , 77 , 79 , 81 – 83 ], survival (19 studies, 28%) [ 20 , 23 , 26 , 30 , 31 , 34 , 42 , 53 , 59 – 62 , 65 , …”

Section: Resultsmentioning

confidence: 99%

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

et al. 2021

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Coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for the most threatening pandemic in modern history. The aim of this systematic review and meta-analysis was to investigate the associations between serum albumin concentrations and COVID-19 disease severity and adverse outcomes. A systematic literature search was conducted in PubMed, from inception to October 30, 2020. Sixty-seven studies in 19,760 COVID-19 patients (6141 with severe disease or poor outcome) were selected for analysis. Pooled results showed that serum albumin concentrations were significantly lower in patients with severe disease or poor outcome (standard mean difference, SMD: − 0.99 g/L; 95% CI, − 1.11 to − 0.88, p < 0.001). In multivariate meta-regression analysis, age (t = − 2.13, p = 0.043), publication geographic area (t = 2.16, p = 0.040), white blood cell count (t = − 2.77, p = 0.008) and C-reactive protein (t = − 2.43, p = 0.019) were significant contributors of between-study variance. Therefore, lower serum albumin concentrations are significantly associated with disease severity and adverse outcomes in COVID-19 patients. The assessment of serum albumin concentrations might assist with early risk stratification and selection of appropriate care pathways in this group.

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Section: Resultsmentioning

confidence: 99%

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

et al. 2021

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“…Overall, they included 4,616 COVID-19 patients, 3,502 (48% males, mean age 52 years) with low severity or who survived and 1,114 (61% males, mean age 64 years) with high severity or who died. Three studies were prospective ( 24 , 30 , 36 ),14 were retrospective ( 22 , 23 , 25 – 29 , 31 , 33 , 34 , 37 – 40 ), whereas the remaining two did not explicitly state the study design ( 32 , 35 ). Disease severity, based on current clinical guidelines, was assessed in 11 studies ( 22 , 23 , 25 , 28 , 30 , 33 , 35 , 37 – 40 ), prolonged viral clearance in two ( 26 , 36 ), transfer to ICU in one ( 29 ), survival in three ( 27 , 31 , 32 ), presence of acute respiratory distress syndrome in one ( 34 ), and multiple end points in one ( 24 ).…”

Section: Resultsmentioning

confidence: 99%

Serum Prealbumin Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis

Zinellu

Mangoni

2021

Front. Med.

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Excessive inflammation and malnutrition are associated with coronavirus disease 2019 (COVID-19) severity and mortality. Combined biomarkers of malnutrition and inflammation, such as serum prealbumin, might be particularly attractive for early risk stratification. We conducted a systematic review and meta-analysis of studies reporting serum prealbumin in patients with COVID-19. We searched PubMed, Web of Science and Scopus, between January and November 2020, for studies reporting data on serum prealbumin, COVID-19 severity, defined as severe illness, prolonged viral load, receiving mechanical ventilation or admitted to intensive care unit (ICU), and mortality. Nineteen studies in 4,616 COVID-19 patients were included in the meta-analysis. Pooled results showed that serum prealbumin concentrations were significantly lower in patients with severe disease and non-survivors (standard mean difference, SMD, −0.92, 95% CI, −1.10 to −0.74, P < 0.001). Extreme heterogeneity was observed (I2 = 77.9%; P < 0.001). In sensitivity analysis, the effect size was not significantly affected when each study was in turn removed (range between −0.86 and −0.95). The Begg's (P = 0.06) and Egger's t-tests (P = 0.26) did not show publication bias. Pooled SMD values were significantly and negatively associated with age (t = −2.18, P = 0.045) and C-reactive protein (t = −3.85, P = 0.002). In our meta-analysis, lower serum prealbumin concentrations were significantly associated with COVID-19 severity and mortality. This combined marker of malnutrition and inflammation might assist with early risk stratification and management in this group.

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“…Previous studies showed that lower PNI was correlated with a lower survival rate in patients having various malignancies, such as esophageal squamous cancer, colorectal cancer, gastric cancer, and lung cancer [30,31,32]. Nowadays, PNI is an important biomarker that can be used to discriminate COVID-19 severity, according to the results of several studies [33][34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Systemic Immune-Inflammation Index (SII), Early Warning Score (ANDC) and Prognostic Nutritional Index (PNI) in Hospitalized Patients with Malignancy, and Their Influence on Mortality from COVID-19

Bilge

Akıllı

Yeşilova

et al. 2021

Preprint

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Introduction: COVID-19 pandemic is a serious cause of increased mortality in patients having malignancy. Therefore, to help predict the clinical progression of those patients with COVID-19 who have multiple comorbidities as cancer, we need various indices whose parameters we can easily measure and rapidly calculate. We evaluated several biological indicators based on inflammation and/or nutritional status, such as systemic immune-inflammation index (SII), early warning score (ANDC) and prognostic nutritional index (PNI) in hospitalized COVID-19 patients with and without malignancies for a prognostic significance. Methodology: This is a retrospective and observational study on 186 patients with SARS-CoV-2, who were diagnosed with COVID-19 by real-time PCR testing and hospitalized due to COVID-19 pneumonia. 75 patients had various malignancies, and the rest (111), having a similar age and comorbidity profile based on propensity score matching, had no malignancy. Results: None of the measures as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (MLR), monocyte to lymphocyte ratio (PLR), SII, PNI or ANDC was found to be significantly different between two groups. Mortality ratio was found to be significantly higher in malignancy group (17,3%). Odds ratio for the mortality, OR:2,39 (%95 CI:1,80 -3,16) was found to be significantly higher for the malignancy group, even though the duration of hospitalization was statistically similar for both groups. PNI was found to be significantly lower for deceased patients compared with survivors in the malignancy group. Contrarily, ANDC was found to be significantly higher for deceased patients in the malignancy group. Conclusions: PNI and ANDC have independent predictive power on determining the in-hospital death in COVID-19 malignancy cases. It is suggested that ANDC seems to be a more sensitive score than SII in COVID-19 cases with malignancies.

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Novel serological biomarkers for inflammation in predicting disease severity in patients with COVID-19

Cited by 93 publications

References 41 publications

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

Serum Prealbumin Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis

Comparison of Systemic Immune-Inflammation Index (SII), Early Warning Score (ANDC) and Prognostic Nutritional Index (PNI) in Hospitalized Patients with Malignancy, and Their Influence on Mortality from COVID-19

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