2022
DOI: 10.1109/jlt.2021.3118103
|View full text |Cite
|
Sign up to set email alerts
|

Novel Sensing Algorithm for Linear Read-Out of Bimodal Waveguide Interferometric Biosensors

Abstract: Biosensors employing photonics integrated circuits, and specifically those that rely on interferometric evanescent wave working principles, have outstanding performances due to the extreme sensitivity exhibited in one-step and direct assay, without the need of amplification. Within the interferometric configurations, the Bimodal Waveguide (BiMW) interferometric sensor stands out due to its demonstrated sensitivity for reallife applications and the simplicity of its design. To overcome the ambiguities that aris… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
7
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
4
1

Relationship

1
4

Authors

Journals

citations
Cited by 12 publications
(7 citation statements)
references
References 44 publications
(52 reference statements)
0
7
0
Order By: Relevance
“…Data processing is performed with a customized software interface that incorporates a recently developed optical phase modulation method to transform the complex interferometric signals into a linear signal (Δ φ ), directly proportional to the change of the refractive index occurring at the sensor area which allows real-time monitoring. 20 The sensor chip is integrated with a five-channel polydimethylsiloxane (PDMS) microfluidic system (channel dimensions = 1.25 mm wide × 500 μm height), for continuous flow and washing of the samples. The fluidic system also includes a syringe pump to guarantee a continuous flow rate of a running buffer and a 6-port injection valve connected to a loop (100 μL) that allows the sequential loading and injection of different samples and solutions.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations
“…Data processing is performed with a customized software interface that incorporates a recently developed optical phase modulation method to transform the complex interferometric signals into a linear signal (Δ φ ), directly proportional to the change of the refractive index occurring at the sensor area which allows real-time monitoring. 20 The sensor chip is integrated with a five-channel polydimethylsiloxane (PDMS) microfluidic system (channel dimensions = 1.25 mm wide × 500 μm height), for continuous flow and washing of the samples. The fluidic system also includes a syringe pump to guarantee a continuous flow rate of a running buffer and a 6-port injection valve connected to a loop (100 μL) that allows the sequential loading and injection of different samples and solutions.…”
Section: Methodsmentioning
confidence: 99%
“…The BiMW biosensor has previously demonstrated its potential for direct, label-free detection of target biomolecules of different nature, like proteins and small molecules, 20,36,37 DNA and RNA sequences, [38][39][40] and also for the direct capture of bacteria. 24,25 These results set the basis for exploring the use of such a device for the detection of viruses, much smaller entities than bacteria (i.e., around 100 nm diameter compared with considerably larger bacteria, as 1-3 μm).…”
Section: Evaluation Of the Bimw Biosensor For Direct Capture And Dete...mentioning
confidence: 99%
See 2 more Smart Citations
“…The performance of these sensors is substantially dependent on the balanced excitation and the controlled recombination of the two modes, which affects the contrast of the interferogram, and the ability to generate a linear output from the sinusoidal interferometric signal [13]. Conventional modal excitation and recombination relies on abrupt transitions between singlemode and multimode waveguides [14]- [16], see Fig. 1(a).…”
Section: Introductionmentioning
confidence: 99%