Novel semi-interpenetrating hydrogel networks with enhanced mechanical properties and thermoresponsive engineered drug delivery, designed as bioactive endotracheal tube biomaterials

Jones, David S.; Andrews, Gavin; Caldwell, Deborah L.; Lorimer, Colin; Gorman, Seán; McCoy, Colin

doi:10.1016/j.ejpb.2012.07.019

Cited by 43 publications

(15 citation statements)

References 49 publications

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“…Due to their swelling ability, hydrogels have been studied extensively for a variety of applications such as drug delivery [3][4][5][6], agricultural applications [7,8], removal of impurities in aqueous solutions [9,10], biosensors [11], and spectrophotometric determination of drugs [12]. In these applications, swelling capacity and thermal, mechanical, and stimuli-responsive properties are of most interest.…”

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive Hydrogels Based on Polyglycerol Crosslinked with Citric and Fatty Acids

Solano-Delgado

Bravo-Sanabria

Ardila-Suárez

et al. 2018

International Journal of Polymer Science

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Polyglycerol-based hydrogels from biodegradable raw materials were synthesized by crosslinking reactions of polyglycerol with citric and fatty acids. Three hydrogels were studied varying molar ratios of crosslinking agent. It was found that crosslink amount, type, and size play a crucial role in swelling, thermal, mechanical, and stimuli-responsive properties. The hydrogels absorption capacity changed in response to temperature and pH external stimuli. The hydrogel with the highest swelling capacity absorbed more than 7 times its own weight at room temperature and pH 5. This material increased 14 times its own weight at pH 10. Creep-recovery tests were performed to study the effect of crosslinking agent on mechanical properties. Deformation and percentage of recovery of synthesized hydrogels were obtained. Formation of hydrogels was confirmed using FTIR, and physicochemical properties were analyzed by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetric (DSC), and Dynamic Mechanical Analysis (DMA). This paper aims to give a contribution to biobased hydrogel knowledge from chemical, physicochemical, and mechanical point of view.

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Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive Hydrogels Based on Polyglycerol Crosslinked with Citric and Fatty Acids

Solano-Delgado

Bravo-Sanabria

Ardila-Suárez

et al. 2018

International Journal of Polymer Science

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“…93,108 One of the most common polymers used for these biomedical applications is poly (N-isopropylacrylamide) (PNIPAM) due to its lower critical solution temperature being very close to body temperature. 109,110 A recent study evaluated PNIPAM-containing hydrogels used as carriers for intramyocardial delivery of brownadipose-derived stem cells in rats with myocardial infarction. 111 The hydrogel displayed rapid, subphysiological phase transition temperatures and was capable of noninvasively delivering a liquid suspension of cells that gels in situ forming a cell-loaded scaffold, essentially isolating treatment to the injection site.…”

Section: Cell Delivery With Tissue-integrating Hydrogelsmentioning

confidence: 99%

It’s All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies

et al. 2018

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Hydrogels provide a regenerative medicine platform with their ability to create an environment that supports transplanted or endogenous infiltrating cells and enables these cells to restore or replace the function of tissues lost to disease or trauma. Furthermore, these systems have been employed as delivery vehicles for therapeutic genes, which can direct and/or enhance the function of the transplanted or endogenous cells. Herein, we review recent advances in the development of hydrogels for cell and non-viral gene delivery through understanding the design parameters, including both physical and biological components, on promoting transgene expression, cell engraftment, and ultimately cell function. Furthermore, this review identifies emerging opportunities for combining cell and gene delivery approaches to overcome challenges to the field.

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“…The addition of another polymer to form a dual interpenetrated network is also an effective method [21,22]. Also methods combining the addition of both inorganic fillers and dual interpenetrated networks have been reported [23].…”

Section: Introductionmentioning

confidence: 98%

Polyaniline-poly(styrene sulfonate) conducting hydrogels reinforced by supramolecular nanofibers and used as drug carriers with electric-driven release

Li¹,

Zeng²,

Wang

et al. 2015

European Polymer Journal

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Novel semi-interpenetrating hydrogel networks with enhanced mechanical properties and thermoresponsive engineered drug delivery, designed as bioactive endotracheal tube biomaterials

Abstract: (2012). Novel semiinterpenetrating hydrogel networks with enhanced mechanical properties and thermoresponsive engineered drug delivery, designed as bioactive endotracheal tube biomaterials.

Cited by 43 publications

References 49 publications

Stimuli-Responsive Hydrogels Based on Polyglycerol Crosslinked with Citric and Fatty Acids

Stimuli-Responsive Hydrogels Based on Polyglycerol Crosslinked with Citric and Fatty Acids

It’s All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies

Polyaniline-poly(styrene sulfonate) conducting hydrogels reinforced by supramolecular nanofibers and used as drug carriers with electric-driven release

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