Abstract:To quantify repaglinide and metformin HCl in largeand combination tablet dosage form simultaneously by RP-HPLC, a simple, precise, and accurate approach has been developed. The Chromatographic conditions employed were Agilent C18 column (150×4.6mm, 5µ) column using a Methanol: Water mixture in gradient mode as the mobile phase at a flow rate of 0.6 ml/min, λmax was found to be 245.5 nm in UV Spectrophotometer. The Retention time (Rt) of the Metformin HCl and Repaglinide was found to be 1.575 and 2.564min respe… Show more
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