Novel ROS-scavenging hydrogel with enhanced anti-inflammation and angiogenic properties for promoting diabetic wound healing

Jiang, Lianghua; Yang, Xu-feng; Zhang, Yijian; He, Dawei; Gao, Yi-jun; Lü, Ke; Hao, Yanming; Gao, Yan; Lu, Daming; Jin, Xuefeng; Li, Chong

doi:10.1016/j.bioadv.2022.213226

Cited by 14 publications

(3 citation statements)

References 37 publications

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“…Consequently, controlling local inflammation in diabetic wounds emerges as a pivotal step in the treatment of diabetic wound healing. [10][11][12] Nanozymes, representing a category of substances that adeptly emulate natural cascade catalytic systems within complex physiological environments, exhibit several advantages, including low cost, efficient catalysis, and robust modifiability. [13][14][15][16] These qualities of nanozymes enable them to effectively overcome the inherent drawbacks of natural enzymes, such as poor stability and strong environmental dependencies.…”

Section: New Conceptsmentioning

confidence: 99%

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Infected wound repair with an ultrasound-enhanced nanozyme hydrogel scaffold

Zhang,

Kang,

Feng

et al. 2023

Mater. Horiz.

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Section: New Conceptsmentioning

confidence: 99%

“…Consequently, controlling local inflammation in diabetic wounds emerges as a pivotal step in the treatment of diabetic wound healing. 10–12…”

Section: Introductionmentioning

confidence: 99%

Infected wound repair with an ultrasound-enhanced nanozyme hydrogel scaffold

Zhang,

Kang,

Feng

et al. 2023

Mater. Horiz.

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“…Furthermore, hydrogels loaded with growth factors such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and keratinocyte growth factor (KGF) have been shown to expedite wound healing and have been validated in clinical settings. [94][95][96][97][98][99][100] In addition, exosomes secreted by cells can also exert similar effects as cells do. Huang et al reported a carboxymethylcellulose hydrogel loaded with plasma exosomes (P-Exos) to enhance wound healing in diabetic mice.…”

Section: Proliferative Hydrogelsmentioning

confidence: 99%

Signaling Pathways Triggering Therapeutic Hydrogels in Promoting Chronic Wound Healing

Chen,

Wu,

Zhang

et al. 2023

Macromolecular Bioscience

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In recent years, there has been a significant increase in the prevalence of chronic wounds, such as pressure ulcers, diabetic foot ulcers, and venous ulcers of the lower extremities. The main contributors to chronic wound formation are bacterial infection, prolonged inflammation, and peripheral vascular disease. However, effectively treating these chronic wounds remains a global challenge. Hydrogels have extensively explored as wound healing dressing because of their excellent biocompatibility and structural similarity to extracellular matrix (ECM). Nonetheless, much is still unknown how the hydrogels promote wound repair and regeneration. Signaling pathways play critical roles in wound healing process by controlling and coordinating cells and biomolecules. Hydrogels, along with their therapeutic ingredients that impact signaling pathways, have the potential to significantly enhance the wound healing process and its ultimate outcomes. Understanding this interaction will undoubtedly provide new insights into developing advanced hydrogels for wound repair and regeneration. This paper reviews the latest studies on classical signaling pathways and potential targets influenced by hydrogel scaffolds in chronic wound healing. This work hopes that it will offer a different perspective in developing more efficient hydrogels for treating chronic wounds.

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