Novel role of PE_PGRS47 in the alteration of mycobacterial cell wall integrity and drug resistance

Li, Wu; Yan, Zifei; Zhang, Nan; Zhang, Zhiyong; Xiang, Xiaohong

doi:10.1007/s00203-023-03515-x

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Morphological Changes In Mtb During Dormancy1

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2024

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“…The pe/ppe genes are found to be associated with the alteration of mycobacterial cell wall integrity. PE_PGRS were reported to thicken the bacterial cell wall to cope with external stimuli by affecting fatty acid metabolism and accelerating the synthesis of lipids such as mycotic acid [ 15 ].…”

Section: Morphological Changes In Mtb During Dormancymentioning

confidence: 99%

Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy

Liu,

Li,

Dai

et al. 2024

CIMB

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Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex, is a zoonotic disease that remains one of the leading causes of death worldwide. Latent tuberculosis infection reactivation is a challenging obstacle to eradicating TB globally. Understanding the gene regulatory network of Mtb during dormancy is important. This review discusses up-to-date information about TB gene regulatory networks during dormancy, focusing on the regulation of lipid and energy metabolism, dormancy survival regulator (DosR), White B-like (Wbl) family, Toxin-Antitoxin (TA) systems, sigma factors, and MprAB. We outline the progress in vaccine and drug development associated with Mtb dormancy.

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Section: Morphological Changes In Mtb During Dormancymentioning

confidence: 99%