Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation

Zeng, Xianyi; Sikka, Suresh C.; Huang, Lüping; Sun, Chunbao; Xu, Chunyan; Jia, Dingwu; Abdel-Mageed, Asim B.; Pottle, Jonathan E.; Taylor, James T.; Li, M

doi:10.1038/pcan.2009.55

Cited by 114 publications

(105 citation statements)

References 32 publications

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“…In addition, TRPV1 and TRPV2 are up-regulated in patients with metastatic cancer (42)(43)(44). Levels of TRPM2 mRNA are elevated in both prostate cancer tissue and in LnCaP and PC3 cell lines (45,46). This suggests that these channels could play an important role in the diagnosis and treatment of prostate carcinoma.…”

Section: Trp Channels and Prostate Cancermentioning

confidence: 99%

Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer

Chen

Luan

et al. 2014

BST

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Section: Trp Channels and Prostate Cancermentioning

confidence: 99%

Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer

Chen

Luan

et al. 2014

BST

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“…TRPM2 was shown to modulate hematopoitic cell death though activation of caspases and poly ADP-ribose polymerase (PARP) cleavage [49]. Knocking down TRPM2 with siRNA technique inhibited the growth of prostate cancer cells rather than of non-cancerous cells [50]. TRPM2 mRNA was found in many primary breast tumors, but no apparent relationship to survival [51].…”

Section: Discussionmentioning

confidence: 99%

Identification of biomarkers for metastatic osteosarcoma based on DNA microarray data

Wang¹

2015

neo

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Osteosarcoma (OS) is a malignant bone tumor very often with pulmonary metastasis and is the main cause of OS mortality. The objective of this study was to screen for possible biomarkers of metastatic OS to explore the mechanisms of pulmonary metastasis of OS through network construction. GSE14359 was downloaded from the Gene Expression Omnibus database, which included 5 samples from conventional OS group with 2 replicates and 4 samples from OS pulmonary metastasis group in duplicate. Differentially expressed genes (DEGs) between two groups were identified by limma packages in R and classical t-test with the threshold of the false discovery rate (FDR) <0.05. The Database for Annotation, Visualization and Integrated Discovery (DAVID) were then used to perform functional annotation (FDR < 0.01). Differential coexpression network was constructed with subspace differential coexpression analysis (SDC), and genes with high degrees in the differential coexpression network were identified.A total of 1344 genes were screened as DEGs, including 677 up-and 667 down-regulated DEGs in the pulmonary metastasis of OS. Thirty-one significantly enriched functions were obtained, such as blood vessel morphogenesis, defense response, cell death and so on. DEGs with high degrees (brain-specific angiogenesis inhibitor 2 (BAI2), formin-like 1 (FMNL1), dualspecificity phosphatase 7 (DUSP7), transient receptor potential melastatin 2 (TRPM2), CBP80/20-dependent translation initiation factor (KIAA0427) and C120rf35) in the differential coexpression network were found. BAI2, FMNL1, DUSP7 and TRPM2 may be useful markers for predicting tumor metastasis and therapeutic targets for the treatment of OS patients with metastasis. Key words: osteosarcoma, differentially expressed genes, differential coexpression network, gene ontologyOsteosarcoma (OS) is the most common primary malignant cancer of the bone in both children and young adults [1]. Moreover, approximately 15-20% of patients present with discernable metastasis [2], frequently for lung [3]. Though the overall recurrent-free survival rate over 5 years remains approximately 65% with neoadjuvant chemotherapy combined with surgery, while when pulmonary metastasis, less than 30% [4]. In addition, neoadjuvant chemotherapy remains controversial in the world [5]. The treatment for OS is very challenging. Hence, it is important to identify molecular targets to prevent pulmonary metastases during the early stage, and further to improve the prognosis of OS patients.The underlying pathogenesis has been difficult to establish because of its heterogeneous histology and complex etiology. Extensive efforts have been made to explore the potential etiology and molecular mechanisms. Reversion-inducing cysteine rich protein with Kazal motifs (RECK), a member of antiangiogenic factors, is down-regulated in OS [6]. The expression level of TGF-β1 is significantly higher in high-grade OS than low-grade OS [7]. Densmore et al. have shown that p53 can effectively reduce the number and the size of lung metastases ...

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“…Expression of TRPM2 has been demonstrated in several tumor entities such as insulinoma [25], hepatocellular carcinoma [25], prostate cancer [26], lymphoma [27], leukemia [28] and lung cancer cell lines [29]. TRPM2 activity increases the susceptibility to cell death [30] probably by overloading cells with Ca 2+ (Fig.…”

Section: Radiosensitizing Ion Channelsmentioning

confidence: 99%

Role of ion channels in ionizing radiation-induced cell death

Huber

Butz

Stegen

et al. 2015

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Neoadjuvant, adjuvant or definitive fractionated radiation therapy are implemented in first line anti-cancer treatment regimens of many tumor entities. Ionizing radiation kills the tumor cells mainly by causing double strand breaks of their DNA through formation of intermediate radicals. Survival of the tumor cells depends on both, their capacity of oxidative defense and their efficacy of DNA repair. By damaging the targeted cells, ionizing radiation triggers a plethora of stress responses. Among those is the modulation of ion channels such as Ca2+-activated K+ channels or Ca2+-permeable nonselective cation channels belonging to the super-family of transient receptor potential channels. Radiogenic activation of these channels may contribute to radiogenic cell death as well as to DNA repair, glucose fueling, radiogenic hypermigration or lowering of the oxidative stress burden. The present review article introduces these channels and summarizes our current knowledge on the mechanisms underlying radiogenic ion channel modulation. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.

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Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation

Cited by 114 publications

References 32 publications

Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer

Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer

Identification of biomarkers for metastatic osteosarcoma based on DNA microarray data

Role of ion channels in ionizing radiation-induced cell death

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