2023
DOI: 10.3390/antibiotics12020304
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Novel Resistance Regions Carrying TnaphA6, blaVIM-2, and blaPER-1, Embedded in an ISPa40-Derived Transposon from Two Multi-Resistant Pseudomonas aeruginosa Clinical Isolates

Abstract: Antibiotic resistance is an alarming problem throughout the world and carbapenem-resistant Pseudomonas aeruginosa has been cataloged as critical in the World Health Organization list of microorganisms in urgent need for the development of new antimicrobials. In this work, we describe two novel resistance regions responsible for conferring a multidrug resistance phenotype to two clinical isolates of P. aeruginosa (Pa873 and Pa6415) obtained from patients hospitalized in the ICU of University Hospital of Uruguay… Show more

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Cited by 6 publications
(6 citation statements)
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“…Similar configurations were identified in the database, differing only in the gene cassettes carried by the class one integrons. These variations included either aminoglycoside, chloramphenicol, or β-lactam resistance genes such as aac(6 ′ )-Ib4, aadA4, catB3, bla OXA-1 , bla IMP-45 , or bla VIM-2 , the latter reported recently by our group in a clinical P. aeruginosa obtained from the same setting [17]. Upstream of the class one integron, most platforms were associated with different Tn3-family elements, typically featuring a resolvase gene and a complete or truncated transposase gene.…”
Section: Discussionmentioning
confidence: 67%
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“…Similar configurations were identified in the database, differing only in the gene cassettes carried by the class one integrons. These variations included either aminoglycoside, chloramphenicol, or β-lactam resistance genes such as aac(6 ′ )-Ib4, aadA4, catB3, bla OXA-1 , bla IMP-45 , or bla VIM-2 , the latter reported recently by our group in a clinical P. aeruginosa obtained from the same setting [17]. Upstream of the class one integron, most platforms were associated with different Tn3-family elements, typically featuring a resolvase gene and a complete or truncated transposase gene.…”
Section: Discussionmentioning
confidence: 67%
“…Moreover, the expression of PER-1 may also explain the resistance to ceftolozane/tazobactam and ceftazidime/avibactam [20,21]. Interestingly, although bla PER-1 is most frequently detected in P. aeruginosa isolates from Europe and the Middle East, to our knowledge, it has only been reported from Uruguay and Chile in the Americas [17,22,23].…”
Section: Discussionmentioning
confidence: 93%
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“…Similar structures have been reported in most pMOS94-like plasmids where ISPa17 preceded carbapenemase carrying Tn402 integrons [ 63 ]. Recently it was hypothesized that the ISPa17 transposase might be capable of the mobilization of adjacent Tn402 integrons resulting in distinct transposon elements [ 68 ]. The Tn7700 transposon had 5bp direct repeats (AAAAC) located up to 26bp apart from each IR, which although unexpected might be suggestive of past transposition events.…”
Section: Resultsmentioning
confidence: 99%