Novel research on Neuroprotective effect of Bacopa monnieri L. against propionic acid induced investigation on autism in Sprague Dawley rat

Abstract

Autism spectrum disorder (ASD) is characterized by complex behavioral and memory impairments resulting from abnormal brain development. The research objective is to identify the lack of understanding of the etiology of autism. The Ayurvedic system of medicine recognizes Bacopa monnieri for their potential nootropic activity to maximize brain and neuronal processes such as learning and memory. Brahmi, Bacopa monnieri has been demonstrated in Ayurvedic preparation as memory booster medicine. The neuroprotective properties of hydroalcoholic extract of Bacopa monnieri against propionic acid-induced neuroprotective effect in autistic rat models were investigated in the present study. The animal species used in the study are adult Sprague Dawley rats of both sexes were divided into four groups and administered the vehicle/extract for 28 days. Between the 22nd and 28th days of the trial, autism was caused by an intracerebroventricular infusion of propionic acid. Rats were treated to the fundamental methods such as different in vivo behavior and memory evaluation procedures during this infusion period, including the actophotometer test and the Morris water maze test. Animals were euthanized on the 29th day of the investigation to obtain brain material. Extracted brain tissues were used to calculate levels of neuroinflammatory markers (TNF-) and histological examination.

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“…• Found that increased working memory Rai et al [15] Extract of Bacopa monneri (CDRI-08) administered to scopolamine-treated amnesic mice Amnesic mice restored the spatial memory. And there is significant upregulation of the GluN2B subunit expression and decline in the acetylcholinesterase activity in prefrontal cortex as well as hippocampus Anamika and Muralidharan [16] Hydroalcoholic extract of Bacopa monnieri was administered orally using nasogastric tube in autistic rat models. To find propionic acid-induced neuroprotective effect…”