“…Human mutations in DRP1 or DYN2 have been associated with neurological impairments (Gonzalez-Jamett et al, 2014; Vanstone et al, 2016; Waterham et al, 2007). Drp1, despite lacking a transmembrane domain, cycles from the cytosol to spots on the mitochondrial outer membrane (Smirnova et al, 1998) by interacting with several proteins, including Fis1, Mff, MiD49, MiD51 and a BAR-domain protein endophilin B1 (Cerveny et al, 2001; Cherok et al, 2017; Fekkes et al, 2000; Gandre-Babbe and van der Bliek, 2008; Otera et al, 2010; Palmer et al, 2011; Tieu and Nunnari, 2000; Zhao et al, 2011). The mitochondrial receptors are suggested to regulate Drp1-mediated fission in response to other signals (Koirala et al, 2013; Lackner et al, 2009; Loson et al, 2014; Loson et al, 2013).…”