2008
DOI: 10.1111/j.1440-1827.2008.02245.x
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Novel recombinant congenic mouse strain developing arthritis with enthesopathy

Abstract: Based on the hypothesis that the complex pathological and immunological manifestations of rheumatoid arthritis (RA) and the related diseases are under the control of multiple gene loci with allelic polymorphism, a recombinant congenic mouse strain was prepared between an MRL/Mp-lpr/ lpr (MRL/lpr) strain, which develops arthritis resembling RA, and a non-arthritic strain C3H/HeJ-lpr/lpr (C3H/lpr). In MRL/ lpr ¥ (MRL/lpr ¥ C3H/lpr) F1 mice, the mice developing severe arthritis were selected based on joint swelli… Show more

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Cited by 7 publications
(9 citation statements)
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References 21 publications
(20 reference statements)
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“…However, these mice mainly exhibit fibrous proliferation in enthesis and fibrous ankylosis, without erosion and bone destruction [29]. McH/lpr-RA1 mice show synovitis, pannus formation and ankylosis, resembling spondyloarthritis [12]. We consider that McH/lpr-RA1 mice are a suitable experimental disease model of spondyloarthritis.…”
Section: Discussionmentioning
confidence: 99%
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“…However, these mice mainly exhibit fibrous proliferation in enthesis and fibrous ankylosis, without erosion and bone destruction [29]. McH/lpr-RA1 mice show synovitis, pannus formation and ankylosis, resembling spondyloarthritis [12]. We consider that McH/lpr-RA1 mice are a suitable experimental disease model of spondyloarthritis.…”
Section: Discussionmentioning
confidence: 99%
“…McH/lpr-RA1 mice were generated using F54 C3H/HeJ- lpr / lpr and MRL/lpr × (MRL/lpr × C3H/lpr) mice. This recombinant congenic strain of mice was designated McH/lpr-RA1 as previously described in the literature [12]. All mice were housed in the animal unit of Tohoku University Medical School, an environmentally controlled and specific pathogen-free facility.…”
Section: Methodsmentioning
confidence: 99%
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“…5b). 50 The mice revealed severe granulomatous synovitis and also fibrous and fibrocartilaginous lesions of articular ligamenta resembling enthesopathy, resulting in ankylosis. This may indicate that a particular genome recombination with that of C3H/lpr mice induced severe arthritis leading to ankylosis, which is not developed by an MRL/lpr genome alone.…”
Section: Genetic Segregation Of Pathological Manifestations Of Collagmentioning
confidence: 99%
“…Three types of mice were used: 40 BALB/c mice, 5 McH/lpr-RA1 mice with arthritis and vasculitis disease (19), and 3 C57BL/10-mdx Jic mice with muscular dystrophy. The mice were housed in the Animal Research Institute of Tohoku University Graduate School of Medicine under specific pathogen-free conditions and had free access to food and water until the beginning of the experiments.…”
Section: Animal Modelsmentioning
confidence: 99%