Novel Reactions of Metal Carbonyl Cluster Compounds

Adams, Richard D.; Horváth, István T.

doi:10.1002/9780470166345.ch3

Cited by 86 publications

(3 citation statements)

References 144 publications

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“…These need to be effective against coronaviruses, including SARS-CoV, MERS-CoV, and SARS-CoV-2 [121,230,231]. These can be viral protease inhibitors [231], enzyme inhibitors [232], antivirals [228,233], immunomodulatory [234], and treatment adjuvants [235]. That is the primary class that has attracted most of the patents [121].…”

Section: Patents On Successful Methodologies On Various Aspects Of Comentioning

confidence: 99%

SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

Rabaan

Al-Ahmed

Sah

et al. 2020

Ann Clin Microbiol Antimicrob

109

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A novel coronavirus (SARS-CoV-2), causing an emerging coronavirus disease (COVID-19), first detected in Wuhan City, Hubei Province, China, which has taken a catastrophic turn with high toll rates in China and subsequently spreading across the globe. The rapid spread of this virus to more than 210 countries while affecting more than 25 million people and causing more than 843,000 human deaths, it has resulted in a pandemic situation in the world. The SARS-CoV-2 virus belongs to the genus Betacoronavirus, like MERS-CoV and SARS-CoV, all of which originated in bats. It is highly contagious, causing symptoms like fever, dyspnea, asthenia and pneumonia, thrombocytopenia, and the severely infected patients succumb to the disease. Coronaviruses (CoVs) among all known RNA viruses have the largest genomes ranging from 26 to 32 kb in length. Extensive research has been conducted to understand the molecular basis of the SARS-CoV-2 infection and evolution, develop effective therapeutics, antiviral drugs, and vaccines, and to design rapid and confirmatory viral diagnostics as well as adopt appropriate prevention and control strategies. To date, August 30, 2020, no effective, proven therapeutic antibodies or specific drugs, and vaccines have turned up. In this review article, we describe the underlying molecular organization and phylogenetic analysis of the coronaviruses, including the SARS-CoV-2, and recent advances in diagnosis and vaccine development in brief and focusing mainly on developing potential therapeutic options that can be explored to manage this pandemic virus infection, which would help in valid countering of COVID-19.

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Section: Patents On Successful Methodologies On Various Aspects Of Comentioning

confidence: 99%

SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

Rabaan

Al-Ahmed

Sah

et al. 2020

Ann Clin Microbiol Antimicrob

109

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“…Phosphine addition to A occurs below the metallic plane trans to the capping sulfido ligand. The formation of the P–Ru bond (κ 1 -PS) is accompanied by the polyhedral expansion of the adjacent hydride-bridged Ru–Ru bond to yield to the opened cluster D in a process that underscores the coordinative flexibility in metal clusters where metal–metal and metal–ligand vertex bonds serve as latent coordination sites for ligand addition and substrate activation reactions. − D lies 25.5 kcal/mol above the reactants (Figure ) and is tangentially related to the expanded clusters found by Planalp and Vahrenkamp in the ligand-induced openings of the phosphinidene-capped tetrahedral clusters FeCo 2 (CO) 9 (μ 3 -PMe) and FeCoWCp′(CO) 8 (μ 3 -PMe) (where Cp′ = Cp, Cp*). , In that study, several PMe 3 - and PPhMe 2 -substituted products were characterized by spectroscopic and crystallographic methods, and phosphine addition (2 equiv) was shown to occur with the scission of two metal–metal bonds through an associative addition process. Scheme illustrates the sequence for the FeCo 2 cluster.…”

Section: Resultsmentioning

confidence: 79%

Polyhedral Flexibility in the Sulfido-Capped Cluster H₂Ru₃(CO)₉(μ₃-S) on Reaction with 2-(Diphenylphosphino)thioanisole (PS) and Reversible Tripodal Rotation of the Chelated PS Ligand in H₂Ru₃(CO)₇(κ²-PS)(μ₃-S)

2019

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Treatment of the tetrahedral cluster H2Ru3(CO)9(μ3-S) (1) with 2-(diphenylphosphino)thioanisole (PS) furnishes the cluster H2Ru3(CO)7(κ2-PS)(μ3-S) (2). Cluster 2, which exhibits a chelated thiophosphine ligand (κ2-PS), exists as a pair of diastereomers with K eq = 1.55 at 298 K that differ in their disposition of ligands at the Ru(CO)(κ2-PS) center. The PS ligand occupies the equatorial sites (Peq,Seq) in the kinetic isomer and axial and equatorial sites (Pax,Seq) in the thermodynamically favored species. The solid-state structure of the kinetic isomer of 2 has been established by X-ray diffraction analysis, and the reversible first-order kinetics to equilibrium have been measured experimentally by NMR spectroscopy and HPLC over the temperature range 293–323 K. The substitution reaction involving 1 and the isomerization of the PS ligand in 2 were investigated by DFT calculations. The computational results support a phosphine-induced expansion of the cluster polyhedron that is triggered by the associative addition of the PS donor to 1. The vertex opening in 1 is selective and leads to the cleavage of a hydride-bridged Ru–Ru bond to give the phosphine-substituted cluster H2Ru3(CO)9(κ1-PS)(μ3-S) as the initial adduct. Chelation of the pendant MeS moiety follows with a loss of CO to give the kinetic substitution product H2Ru3(CO)7(κ2-Peq,Seq)(μ3-S) (2). The observed isomerization of the PS ligand in 2 is best explained by a tripodal rotation of the CO and PS groups at the Ru(CO)(κ2-PS) center that is preceded by a regiospecific migration of one of the edge-bridging hydrides to the nonhydride-bridged Ru–Ru bond in 2.

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“…Simultaneously with hydrogen deuterium exchange the substitution of bridging chlorine for methylate anion occurs by scheme characteristic for substitution of three electron bridging ligands in triangular clusters [15][16][17][18].…”

Section: Resultsmentioning

confidence: 99%

H–D exchange in metal carbene complexes: Structure of cluster (μ-H)(μ-OCD3)Os3(CO)9{:C(CD3)NC2H8O}

Savkov

Максаков

Kuratieva

2015

Journal of Molecular Structure

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Novel Reactions of Metal Carbonyl Cluster Compounds

Cited by 86 publications

References 144 publications

SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

Polyhedral Flexibility in the Sulfido-Capped Cluster H₂Ru₃(CO)₉(μ₃-S) on Reaction with 2-(Diphenylphosphino)thioanisole (PS) and Reversible Tripodal Rotation of the Chelated PS Ligand in H₂Ru₃(CO)₇(κ²-PS)(μ₃-S)

H–D exchange in metal carbene complexes: Structure of cluster (μ-H)(μ-OCD3)Os3(CO)9{:C(CD3)NC2H8O}

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Novel Reactions of Metal Carbonyl Cluster Compounds

Cited by 86 publications

References 144 publications

SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

Polyhedral Flexibility in the Sulfido-Capped Cluster H2Ru3(CO)9(μ3-S) on Reaction with 2-(Diphenylphosphino)thioanisole (PS) and Reversible Tripodal Rotation of the Chelated PS Ligand in H2Ru3(CO)7(κ2-PS)(μ3-S)

H–D exchange in metal carbene complexes: Structure of cluster (μ-H)(μ-OCD3)Os3(CO)9{:C(CD3)NC2H8O}

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Polyhedral Flexibility in the Sulfido-Capped Cluster H₂Ru₃(CO)₉(μ₃-S) on Reaction with 2-(Diphenylphosphino)thioanisole (PS) and Reversible Tripodal Rotation of the Chelated PS Ligand in H₂Ru₃(CO)₇(κ²-PS)(μ₃-S)