Novel quinoline-based oxadiazole derivatives induce G2/M arrest and apoptosis in human breast cancer MCF-7 cell line

Synthesis, Anticancer Evaluation and DNA‐Binding Spectroscopic Insights of Quinoline‐Based 1,3,4‐Oxadiazole‐1,2,3‐triazole Conjugates

“…[15] Quinoline based oxadiazoles and triazoles are already reported to possess anticancer activity and induce apoptosis in various cancer cells. [16][17] Figure 1 illustrates 1,3,4-oxadiazole and quinoline based drugs and some reported quinoline based 1,3,4-oxadiazole and 1,2,3triazole inhibitors which prompted us to design such inhibitors. [17][18][19] The combination of two or more biologically active pharmacophoric moieties in the architecture of single molecular scaffold is evolving as promising agents in drug designing.…”

“…Carboxyamido‐triazole (CAI), is a signal transduction inhibitor that induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl‐2 . Quinoline based oxadiazoles and triazoles are already reported to possess anticancer activity and induce apoptosis in various cancer cells . Figure illustrates 1,3,4‐oxadiazole and quinoline based drugs and some reported quinoline based 1,3,4‐oxadiazole and 1,2,3‐triazole inhibitors which prompted us to design such inhibitors .…”

A Facile Synthesis of Substituted 2‐(5‐(Benzylthio)‐1,3,4‐oxadiazol‐2‐yl)pyrazine Using Microwave Irradiation and Conventional Method with Antioxidant and Anticancer Activities

“…In continuation of our work , on the synthesis of bioactive compounds, we have synthesized some 1,3,4‐oxadiazole analogues. The synthetic protocols employed for the synthesis of oxadiazole derivatives 3 and 4 are presented in Schemes , , and , respectively.…”

Supramolecular Interactions of Bambus[6]urils with Quinoline and 6‐Hydroxyisoquinoline Hydrochloride Salts

“…Its electrophilic substitution occurs only on the benzene ring, and nucleophilic substitution occurs on the pyridine ring due to the fact that the electron cloud density on the benzene ring is higher than that of the pyridine ring . A variety of derivatives of quinoline have been discovered, and most of them are pharmacologically and biologically active, such as bactericidal, antidepressant, antihypertensive, anti‐malarial, anti‐tumor, anti‐cancer, and anti‐HIV drugs . Recently, more and more quinoline derivatives have been developed as new organic ligands for structural and functionalizational investigation of the coordination compounds, It can also form catalysts with transition metals .…”

“…[28] A variety of derivatives of quinoline have been discovered, and most of them are pharmacologically and biologically active, such as bactericidal, antidepressant, antihypertensive, anti-malarial, anti-tumor, anti-cancer, and anti-HIV drugs. [29][30][31][32][33] Recently, more and more quinoline derivatives have been developed as new organic ligands for structural and functionalizational investigation of the coordination compounds, [34][35][36] It can also form catalysts with transition metals. [37] The above significative development of quinoline compounds inspired us to investigate the supramolecular interactions between quinoline hydrochloride salts and bambus [6]urils (Scheme 1).…”