Novel QUEST MRI In Vivo Measurement of Noise-induced Oxidative Stress in the Cochlea

Kühl, André; Dixon, Angela R.; Hali, Mirabela; Apawu, Aaron K.; Muca, Antonela; Sinan, Moaz; Warila, James; Braun, Rosemary; Berkowitz, Bruce A.; Holt, Avril Genene

doi:10.1038/s41598-019-52439-4

Cited by 9 publications

(5 citation statements)

References 54 publications

(57 reference statements)

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“…Jerk amplitudes are used to elicit far-field potential responses generated by irregular primary vestibular afferent discharges [ 152 , 153 ]. Studies have shown that vestibular damage can occur due to brief exposure to elevated sound levels and sustained exposure to low-frequency continuous sound at more moderate levels [ 154 , 155 , 156 , 157 ]. A study of 258 military personnel found that vestibular damage from intense noise exposure was corelated with asymmetric NIHL [ 138 ].…”

Section: Pathophysiologymentioning

confidence: 99%

Noise-Induced Hearing Loss

Natarajan

Batts

Stanković

2023

JCM

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Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural hearing loss, after age-related hearing loss, and affects approximately 5% of the world’s population. NIHL is associated with substantial physical, mental, social, and economic impacts at the patient and societal levels. Stress and social isolation in patients’ workplace and personal lives contribute to quality-of-life decrements which may often go undetected. The pathophysiology of NIHL is multifactorial and complex, encompassing genetic and environmental factors with substantial occupational contributions. The diagnosis and screening of NIHL are conducted by reviewing a patient’s history of noise exposure, audiograms, speech-in-noise test results, and measurements of distortion product otoacoustic emissions and auditory brainstem response. Essential aspects of decreasing the burden of NIHL are prevention and early detection, such as implementation of educational and screening programs in routine primary care and specialty clinics. Additionally, current research on the pharmacological treatment of NIHL includes anti-inflammatory, antioxidant, anti-excitatory, and anti-apoptotic agents. Although there have been substantial advances in understanding the pathophysiology of NIHL, there remain low levels of evidence for effective pharmacotherapeutic interventions. Future directions should include personalized prevention and targeted treatment strategies based on a holistic view of an individual’s occupation, genetics, and pathology.

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Section: Pathophysiologymentioning

confidence: 99%

Noise-Induced Hearing Loss

Natarajan

Batts

Stanković

2023

JCM

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“…Free radicals are paramagnetic, and during times of OS they cause shortening of spin-lattice relaxation time (T1) and thus prolongation of the spin-lattice relaxation rate (R1). By assessing a reduction in R1 after a quench with anti-oxidant treatment during the scan (e.g., administration of alpha-lipoic acid) this weights the specific contribution of ROS to the increased R1 ( 56 ). However, relaxation rates may be impacted by factors that are not related to ROS—such as water and oxygen content ( 57 , 58 ).…”

Section: Magentic Resonance Imagingmentioning

confidence: 99%

Oxidative stress in multiple sclerosis—Emerging imaging techniques

et al. 2023

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While conventional magnetic resonance imaging (MRI) is central to the evaluation of patients with multiple sclerosis, its role in detecting the pathophysiology underlying neurodegeneration is more limited. One of the common outcome measures for progressive multiple sclerosis trials, atrophy on brain MRI, is non-specific and reflects end-stage changes after considerable neurodegeneration has occurred. Identifying biomarkers that identify processes underlying neurodegeneration before it is irreversible and that reflect relevant neurodegenerative pathophysiology is an area of significant need. Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis of multiple neurodegenerative diseases, including multiple sclerosis. Imaging markers related to inflammation, myelination, and neuronal integrity have been areas of advancement in recent years but oxidative stress has remained an area of unrealized potential. In this article we will begin by reviewing the role of oxidative stress in the pathogenesis of multiple sclerosis. Chronic inflammation appears to be directly related to the increased production of reactive oxygen species and the effects of subsequent oxidative stress appear to be amplified by aging and accumulating disease. We will then discuss techniques in development used in the assessment of MS as well as other models of neurodegenerative disease in which oxidative stress is implicated. Multiple blood and CSF markers of oxidative stress have been evaluated in subjects with MS, but non-invasive imaging offers major upside in that it provides real-time assessment within the brain.

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“…This method can potentially broaden our understanding of the regional specificity of oxidative stress, can help evaluate novel antioxidant treatments in animal models or patients with NDs, and may guide personalized treatment decisions in the future. QUEST-MRI has already been successfully applied in rodent models and humans [170,171]. However, studies on patients with NDs are currently lacking.…”

Section: Iron-sensitive Magnetic Resonance Imaging To Unravel the Gen...mentioning

confidence: 99%

Neuroimaging Methods to Map In Vivo Changes of OXPHOS and Oxidative Stress in Neurodegenerative Disorders

Prasuhn

Kunert

Brüggemann

2022

IJMS

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Mitochondrial dysfunction is a pathophysiological hallmark of most neurodegenerative diseases. Several clinical trials targeting mitochondrial dysfunction have been performed with conflicting results. Reliable biomarkers of mitochondrial dysfunction in vivo are thus needed to optimize future clinical trial designs. This narrative review highlights various neuroimaging methods to probe mitochondrial dysfunction. We provide a general overview of the current biological understanding of mitochondrial dysfunction in degenerative brain disorders and how distinct neuroimaging methods can be employed to map disease-related changes. The reviewed methodological spectrum includes positron emission tomography, magnetic resonance, magnetic resonance spectroscopy, and near-infrared spectroscopy imaging, and how these methods can be applied to study alterations in oxidative phosphorylation and oxidative stress. We highlight the advantages and shortcomings of the different neuroimaging methods and discuss the necessary steps to use these for future research. This review stresses the importance of neuroimaging methods to gain deepened insights into mitochondrial dysfunction in vivo, its role as a critical disease mechanism in neurodegenerative diseases, the applicability for patient stratification in interventional trials, and the quantification of individual treatment responses. The in vivo assessment of mitochondrial dysfunction is a crucial prerequisite for providing individualized treatments for neurodegenerative disorders.

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Novel QUEST MRI In Vivo Measurement of Noise-induced Oxidative Stress in the Cochlea

Cited by 9 publications

References 54 publications

Noise-Induced Hearing Loss

Noise-Induced Hearing Loss

Oxidative stress in multiple sclerosis—Emerging imaging techniques

Neuroimaging Methods to Map In Vivo Changes of OXPHOS and Oxidative Stress in Neurodegenerative Disorders

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