Novel Quantitative Techniques for Assessing Regional and Global Function and Structure Based on Modern Imaging Modalities: Implications for Normal Variation, Aging and Diseased States

Basu, Sandip; Zaidi, Habib; Houseni, Mohamed; Bural, Gonca; Udupa, Jay; Acton, Paul D.; Torigian, Drew A.; Alavi, Abass

doi:10.1053/j.semnuclmed.2007.01.005

Cited by 93 publications

(64 citation statements)

References 37 publications

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“…In addition to respiratory motion, partial volume effect which arises from the finite spatial resolution of the scanner also results in inaccurate PET image quantification, particularly when the tumor size is less than two to three times the scanner's spatial resolution [19][20][21]. While gating may reduce motion artifacts, it fails to correct the partial volume effect (PVE) and PVE is most likely to dominate over motion effects for small lesions [16].…”

Section: Introductionmentioning

confidence: 99%

Application of Partial Volume Effect Correction and 4D PET in the Quantification of FDG Avid Lung Lesions

et al. 2014

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Purpose: The aim of this study is to assess a software-based method with semiautomated correction for partial volume effect (PVE) to quantify the metabolic activity of pulmonary malignancies in patients who underwent non-gated and respiratory-gated 2-deoxy-2-[ 18 F]fluoro-D-glucose (FDG)-positron emission tomography (PET)/x-ray computed tomography(CT). Procedures: The study included 106 lesions of 55 lung cancer patients who underwent respiratory-gated FDG-PET/CT for radiation therapy treatment planning. Volumetric PET/CT parameters were determined by using 4D PET/CT and non-gated PET/CT images. We used a semiautomated program employing an adaptive contrast-oriented thresholding algorithm for lesion delineation as well as a lesion-based partial volume effect correction algorithm. We compared respiratory-gated parameters with non-gated parameters by using pairwise comparison and interclass correlation coefficient assessment. In a multivariable regression analysis, we also examined factors, which can affect quantification accuracy, including the size of lesion and the location of tumor. Results: This study showed that quantification of volumetric parameters of 4D PET/CT images using an adaptive contrast-oriented thresholding algorithm and 3D lesion-based partial volume correction is feasible. We observed slight increase in FDG uptake by using PET/CT volumetric parameters in comparison of highest respiratory-gated values with non-gated values. After correction for partial volume effect, the mean standardized uptake value (SUVmean) and total lesion glycolysis (TLG) increased substantially (p value G0.001). However, we did not observe a clinically significant difference between partial volume corrected parameters of respiratory-gated and non-gated PET/CT scans. Regression analysis showed that tumor volume was the main predictor of quantification inaccuracy caused by partial volume effect.Electronic supplementary material The online version of this article (doi:10.1007/s11307-014-0776-6) contains supplementary material, which is available to authorized users.Correspondence to: Abass Alavi; e-mail: abass.alavi@uphs.upenn.edu Conclusions: Based on this study, assessment of volumetric PET/CT parameters and partial volume effect correction for accurate quantification of lung malignant lesions by using respiratory non-gated PET images are feasible and it is comparable to gated measurements. Partial volume correction increased both the respiratory-gated and non-gated values significantly and appears to be the dominant source of quantification error of lung lesions.

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Section: Introductionmentioning

confidence: 99%

Application of Partial Volume Effect Correction and 4D PET in the Quantification of FDG Avid Lung Lesions

et al. 2014

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“…31 Application of PET/CT in nuclear medicine or radiology is a detection and quantitation task based on standardized uptake value (SUV). [32][33][34] Physicians can sometimes mentally construct an ideal image even if the images are with artifacts. If the artifacts are not significant, they can simply be read through.…”

Section: Introductionmentioning

confidence: 99%

Attenuation Correction Strategies for Positron Emission Tomography/Computed Tomography and 4-Dimensional Positron Emission Tomography/Computed Tomography

Pan

Zaidi

2013

PET Clinics

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“…The purpose of this study was to prospectively investigate the value of multimodal MRI and PET/CT studies with either 18 F-Fluorocholine (FCH) or 11 C-acetate (AC) in patients assumed to be cured after curative radiotherapy for prostate cancer based on a long term (>5 years after radiotherapy) low and stable PSA levels and no clinical evidence of recurrence.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Post-Treatment MR and PET/CT Imaging in Prostate Cancer Patients in Complete Remission after Curative Radiotherapy with or without Androgen Deprivation: The Image of Cure

Miralbell¹,

Vees²

2012

J Nucl Med Radiat Ther

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Purpose: To investigate the risk of false positive MRI and 18F-Fluorocholine (FCH) or 11Cacetate (AC) PET/ CT in prostate cancer patients with long term biochemical and clinical remission after curative radiation therapy (RT). Methods and Materials:Twenty patients underwent MRI studies including T2-weighted, diffusion weighted, dynamic contrast-enhanced, and spectroscopic imaging. Nine of these patients were selected to have FCH and 10 AC PET/CT studies.

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Novel Quantitative Techniques for Assessing Regional and Global Function and Structure Based on Modern Imaging Modalities: Implications for Normal Variation, Aging and Diseased States

Cited by 93 publications

References 37 publications

Application of Partial Volume Effect Correction and 4D PET in the Quantification of FDG Avid Lung Lesions

Application of Partial Volume Effect Correction and 4D PET in the Quantification of FDG Avid Lung Lesions

Attenuation Correction Strategies for Positron Emission Tomography/Computed Tomography and 4-Dimensional Positron Emission Tomography/Computed Tomography

Long-Term Post-Treatment MR and PET/CT Imaging in Prostate Cancer Patients in Complete Remission after Curative Radiotherapy with or without Androgen Deprivation: The Image of Cure

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