Novel Pyrrolo[3,2-f]quinolines: Synthesis and Antiproliferative Activity

Synthesis and Pharmacological Evaluation of New 3,4-Dihydroisoquinolin Derivatives Containing Heterocycle as Potential Anticonvulsant Agents

“…In compound series II, 8-hexyloxy-4,5-dihydro-[1.2.4]triazole quinoline-1-one was the most potent anticonvulsant, with an ED 50 value of 17.17 mg/kg in the maximal electroshock (MES) test [7,8]. Moreover, numerous studies have previously shown that quinoline and isoquinoline derivatives have similar biological activity, such as antiproliferative [9], antihypertensive [10], analgesics [11], and antidepressant effects [12]. Therefore, we speculated that [1,2,4]triazolo [4,3-a]isoquinolines derivatives would have antiseizure activity.…”

Tetrahydroquinoline and tetrahydroisoquinoline mixed ligand rhenium complexes with the SNS/S donor atom set

“…12 -16 In addition, hydrogenated quinoline moieties are present as structural fragments in Amsacrine, Bruneomycinum, Vincristine and Vinblastinum, which are widely used in oncology. 17,18 1 H and 13 C NMR spectra were determined on a Varian Inova-400 (400 MHz for 1 H, 100 MHz for 13 C) instrument at 303 K with CDCl 3 as a solvent and internal standard (δ = 7.25 ppm for CHCl 3 ). Infrared spectra (IR) were recorded on a Perkin Elmer FTIR Specord 2000 spectrometer in the indicated phase.…”

Silyl modification of biologically active compounds. 11. Synthesis, physico‐chemical and biological evaluation of N‐(trialkoxysilylalkyl)tetrahydro(iso,silaiso) quinoline derivatives

“…Quinoline or hydrogenated quinoline moieties are present as structural fragments in Amsacrine, Bruneomycinum, Vincristine and Vinblastinum, which are widely used in oncology. 6,7 According to the literature data, some quinoline or tetrahydroquinoline ringcontaining compounds possess antiproliferative activity by inhibition of topoisomerase II 8,9 or topoisomerase I, 10 or have cytostatic effects. 11,12 It has been reported that tetrahydro(iso)quinoline based compounds display affinity to serotonin (5-HT 1A ), 13,14 dopamine 15 and NMDA receptors, 16 and possess sedative properties.…”