Novel putative pathogenic viruses identified in pangolins by mining metagenomic data

Ning, Songyi; Dai, Ziyuan; Zhao, Chunyan; Feng, Zhanghao; Jin, Kexin; Yang, Shixing; Shen, Qing; Wang, Xiaochun; Sun, Runfeng; Zhang, Wen

doi:10.1002/jmv.27564

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…It also contains the conserved domains expected in functional retroviruses, although the terminal end of the env gene is missing (either from true truncation or incomplete assembly). The virus is most closely related to AdCPG/aus/1 sampled from the lung tissue of Malayan pangolins (Ning et al, 2022). BLASTn analysis of the complete genome of AdCPG/aus/1 showed the absence of this genome in any bat reference genome on NCBI/GenBank.…”

Section: Resultsmentioning

confidence: 99%

Faecal virome of the Australian grey-headed flying fox from urban/suburban environments contains novel coronaviruses, retroviruses and sapoviruses

Brussel

Mahar

Ortiz-Báez

et al. 2022

Preprint

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Bats are important reservoirs for viruses of public health and veterinary concern. Virus studies in Australian bats usually target the families Paramyxoviridae, Coronaviridae and Rhabdoviridae, with little known about their overall virome composition. We used metatranscriptomic sequencing to characterise the faecal virome of grey-headed flying foxes from three colonies in urban/suburban locations from two Australian states. We identified viruses from three mammalian-infecting (Coronaviridae, Caliciviridae, Retroviridae) and one possible mammalian-infecting (Birnaviridae) family. Of particular interest were a novel bat betacoronavirus (subgenus Nobecovirus) and a novel bat sapovirus (Caliciviridae), the first identified in Australian bats, as well as a potentially exogenous retrovirus. The novel betacoronavirus was detected in two sampling locations 1,375 km apart and falls in a viral lineage likely with a long association with bats. This study highlights the utility of unbiased sequencing of faecal samples for identifying novel viruses and revealing broad-scale patterns of virus ecology and evolution.

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Section: Resultsmentioning

confidence: 99%

Faecal virome of the Australian grey-headed flying fox from urban/suburban environments contains novel coronaviruses, retroviruses and sapoviruses

Brussel

Mahar

Ortiz-Báez

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Previous virome investigations of diseased pangolins have focused on vertebrate-hosted viruses, including Reoviridae , Parvoviridae , Papillomaviridae , Circoviridae , Flaviviridae , and Picornaviridae ( Liu et al, 2019 ; Ning et al, 2022 ; Yang et al, 2021 ). In this study, we provided more detailed information and confirmed that these viruses are carried by healthy pangolins.…”

Section: Discussionmentioning

confidence: 99%

Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses

Tian

Liu

et al. 2022

Zoological Research

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Previous studies have identified multiple viruses in dead or severely diseased pangolins, but descriptions of the virome in healthy pangolins are lacking. This poses a greater risk of cross-species transmission due to poor preventive awareness and frequent interactions with breeders. In this study, we investigated the viral composition of 34 pangolins with no signs of disease at the time of sampling and characterized a large number of arthropod-associated viruses belonging to 11 families and vertebrate viruses belonging to eight families, including those with pathogenic potential in humans and animals. Several important vertebrate viruses were identified in the pangolins, including parvovirus, pestivirus, and picobirnavirus. The picobirnavirus was clustered with human and grey teal picobirnaviruses. Viruses with cross-species transmission ability were also identified, including circovirus, rotavirus, and astrovirus. Our study revealed that pangolins are frequently exposed to arthropod-associated viruses in the wild and can carry many vertebrate viruses under natural conditions. This study provides important insights into the virome of pangolins, underscoring the importance of monitoring potential pathogens in healthy pangolins to prevent outbreaks of infectious diseases in domesticated animals and humans.

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“…By using data mining approaches, Feng Z et al suggested identifying additional suspected harmful viruses in pangolins. They found two genomes of the genus Gemykibivirus and nine types of bat-associated circovirus, respectively [11]. With the implementation of five distinct text different classifiers that perform well in tweet categorization, Rahman R presented a real-time Twitter data mining method for inferring user mobile perceptions [12].…”

Section: Related Workmentioning

confidence: 99%

Prediction of English Teacher Career Development Based on Data Mining and Time Series Model

Fan

2024

SCPE

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With the gradual growth of the teaching profession, the teaching profession is facing new trends in reform and development, and the same dilemma exists for English teachers’ career development and planning. To this end, the study first uses a modified K-means clustering method to cluster and analyse the factors affecting English teachers’ professional development, forming a system of indicators on English teachers’ professional development. The Long Short-Term Memory (LSTM) network employed the time-series features to create a time-series model, and the Support Vector Machine (SVM) was used to forecast the course of English teachers’ career development. To assess the current career status of English teachers and their impact on people and organizations, this study proposes a career prediction model for English teachers. This model utilizes data mining and time series modeling to provide accurate predictions. In accordance with the experimental findings, the precision of the upgraded K-Means model was 98.58%, and the error between the projected sample data and the actual sample data for the training of the trend prediction model for English teachers’ career growth was 0.032. It was able to accurately predict teachers’ career development and explore the specific factors affecting English teachers’ career development, so as to solve the problems in teachers’ career development.

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Novel putative pathogenic viruses identified in pangolins by mining metagenomic data

Cited by 9 publications

References 46 publications

Faecal virome of the Australian grey-headed flying fox from urban/suburban environments contains novel coronaviruses, retroviruses and sapoviruses

Faecal virome of the Australian grey-headed flying fox from urban/suburban environments contains novel coronaviruses, retroviruses and sapoviruses

Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses

Prediction of English Teacher Career Development Based on Data Mining and Time Series Model

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