Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway

Yang, Xiaoxiao; Liu, Zhigang; Fang, Mengyuan; Zou, Tingfeng; Zhang, Zhen; Meng, Xianshe; Wang, Tianxiang; Meng, Huawen; Chen, Yuanli; Duan, Yajun; Li, Qing-Shan

doi:10.1016/j.ejmech.2023.115602

Cited by 8 publications

(1 citation statement)

References 61 publications

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“…PTE is a dimethyl analog of resveratrol, which has various pharmacological effects such as anticancer, anti‐inflammatory, and antioxidant. Recently, Yang and their team designed and synthesized a novel pterostilbene chalcone, dihydropyrazole derivative and demonstrated that it inhibited oxidative stress to ameliorate doxorubicin‐induced heart failure 19 . In the present study, we found that PTE treatment reversed the H 2 O 2 ‐induced decrease in cell viability and increase in apoptosis rate and intracellular ROS level in cardiomyocytes, demonstrating its strong antioxidative ability.…”

Section: Discussionsupporting

confidence: 63%

Pterostilbene protects against H₂O₂‐induced oxidative stress by regulating GAS6/Axl signaling in HL‐1 cells

Di,

Zhao,

et al. 2024

Cell Biochemistry & Function

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Pterostilbene (PTE, trans‐3,5‐dimethoxy‐4′‐hydroxystilbene), a natural plant polyphenol, possesses numerous pharmacological effects, including antioxidant, antidiabetic, antiatherosclerotic, and neuroprotective aspects. This study aims to investigate whether PTE plays a protective role against oxidative stress injury by GAS6/Axl signaling pathway in cardiomyocytes. Hydrogen peroxide (H2O2)‐induced oxidative stress HL‐1 cells were used as models. The mechanism by which PTE protected oxidative stress is investigated by combining cell viability, cell ROS levels, apoptosis assay, molecular docking, quantitative real‐time PCR, and western blot analysis. GAS6 shRNA was performed to investigate the involvement of GAS6/Axl pathways in PTE's protective role. The results showed that PTE treatment improved the cell morphology and viability, and inhibited the apoptosis rate and ROS levels in H2O2‐injured HL‐1 cells. Particularly, PTE treatment upregulated the levels of GAS6, Axl, and markers related to oxidative stress, apoptosis, and mitochondrial function related. Molecular docking showed that PTE and GAS6 have good binding ability. Taken together, PTE plays a protective role against oxidative stress injury through inhibiting oxidative stress and apoptosis and improving mitochondrial function. Particularly, GAS6/Axl axis is the surprisingly prominent in the PTE‐mediated pleiotropic effects.

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Section: Discussionsupporting

confidence: 63%

Pterostilbene protects against H₂O₂‐induced oxidative stress by regulating GAS6/Axl signaling in HL‐1 cells

Di,

Zhao,

et al. 2024

Cell Biochemistry & Function

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Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline

Dutta,

Rakshe,

Maurya

et al. 2023

Ageing Research Reviews

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Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice

Guo,

Liu,

Han

et al. 2024

Biochemical Pharmacology

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Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway

Cited by 8 publications

References 61 publications

Pterostilbene protects against H₂O₂‐induced oxidative stress by regulating GAS6/Axl signaling in HL‐1 cells

Pterostilbene protects against H₂O₂‐induced oxidative stress by regulating GAS6/Axl signaling in HL‐1 cells

Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline

Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice

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Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway

Cited by 8 publications

References 61 publications

Pterostilbene protects against H2O2‐induced oxidative stress by regulating GAS6/Axl signaling in HL‐1 cells

Pterostilbene protects against H2O2‐induced oxidative stress by regulating GAS6/Axl signaling in HL‐1 cells

Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline

Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice

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Pterostilbene protects against H₂O₂‐induced oxidative stress by regulating GAS6/Axl signaling in HL‐1 cells

Pterostilbene protects against H₂O₂‐induced oxidative stress by regulating GAS6/Axl signaling in HL‐1 cells