2023
DOI: 10.1016/j.ejmech.2023.115602
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Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway

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Cited by 12 publications
(2 citation statements)
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“…PTE is a dimethyl analog of resveratrol, which has various pharmacological effects such as anticancer, anti‐inflammatory, and antioxidant. Recently, Yang and their team designed and synthesized a novel pterostilbene chalcone, dihydropyrazole derivative and demonstrated that it inhibited oxidative stress to ameliorate doxorubicin‐induced heart failure 19 . In the present study, we found that PTE treatment reversed the H 2 O 2 ‐induced decrease in cell viability and increase in apoptosis rate and intracellular ROS level in cardiomyocytes, demonstrating its strong antioxidative ability.…”
Section: Discussionsupporting
confidence: 63%
“…PTE is a dimethyl analog of resveratrol, which has various pharmacological effects such as anticancer, anti‐inflammatory, and antioxidant. Recently, Yang and their team designed and synthesized a novel pterostilbene chalcone, dihydropyrazole derivative and demonstrated that it inhibited oxidative stress to ameliorate doxorubicin‐induced heart failure 19 . In the present study, we found that PTE treatment reversed the H 2 O 2 ‐induced decrease in cell viability and increase in apoptosis rate and intracellular ROS level in cardiomyocytes, demonstrating its strong antioxidative ability.…”
Section: Discussionsupporting
confidence: 63%
“…Myocardium inhibits myocardial fibrosis [ 19 ], reduces ischemia–reperfusion-induced inflammation [ 20 ], and prevents hypertensive heart failure [ 21 , 22 ]. The inhibition of oxidative stress [ 23 , 24 ] reduced lipid peroxidation, maintained thioredoxin reductase activity, promoted GST and glutaredoxin activity, and reduced nuclear factor erythroid 2 (Nrf2) and AMP-activated protein kinase (AMPK) activation [ 25 , 26 , 27 ]. However, reports on the effects of PTE on CTRCD are limited.…”
Section: Introductionmentioning
confidence: 99%