Novel Proteoliposome-Based Vaccine against E. coli: A Potential New Tool for the Control of Bovine Mastitis

Quiroga, John; Vidal, Sonia; Siel, Daniela; Caruffo, Mario; Valdés, Andrea; Cabrera, Gonzalo; Lapierre, Lissette; Sáenz, Leonardo

doi:10.3390/ani12192533

Cited by 4 publications

(2 citation statements)

References 97 publications

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“…However, no data are available on its use and protection against intramammary invasions [ 306 ]. Quiroga et al [ 307 ] assessed the efficacy of a novel vaccine against mastitis using proteoliposomes obtained from E. coli in a murine model of coliform mastitis. They demonstrated that the proteoliposome vaccine was safe, immunogenic, and effective against an experimental model of E. coli mastitis, decreasing the bacterial count and tissue damage.…”

Section: Role Of Immunization and Its Constraintsmentioning

confidence: 99%

Advances in Diagnostic Approaches and Therapeutic Management in Bovine Mastitis

Kour

Sharma

Balaji

et al. 2023

Veterinary Sciences

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Mastitis causes huge economic losses to dairy farmers worldwide, which largely negatively affects the quality and quantity of milk. Mastitis decreases overall milk production, degrades milk quality, increases milk losses because of milk being discarded, and increases overall production costs due to higher treatment and labour costs and premature culling. This review article discusses mastitis with respect to its clinical epidemiology, the pathogens involved, economic losses, and basic and advanced diagnostic tools that have been used in recent times to diagnose mastitis effectively. There is an increasing focus on the application of novel therapeutic approaches as an alternative to conventional antibiotic therapy because of the decreasing effectiveness of antibiotics, emergence of antibiotic-resistant bacteria, issue of antibiotic residues in the food chain, food safety issues, and environmental impacts. This article also discussed nanoparticles’/chitosan’s roles in antibiotic-resistant strains and ethno-veterinary practices for mastitis treatment in dairy cattle.

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Section: Role Of Immunization and Its Constraintsmentioning

confidence: 99%

Advances in Diagnostic Approaches and Therapeutic Management in Bovine Mastitis

Kour

Sharma

Balaji

et al. 2023

Veterinary Sciences

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“…Вакцинопрофилактика занимает значительное место в борьбе с инфекционными болезнями. Применение вакцин позволяет не только снизить количество больных маститом коров, но и значительно улучшить качество получаемой молочной продукции [2,56,57].…”

Section: Introductionunclassified

Etiology and epizootology of bovine mastitis (analytical review)

Andreeva,

Evgrafova,

Voronina

et al. 2024

Veterinariâ segodnâ

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Mastitis is one of the most common global diseases of dairy cattle, it is detected in 5–36% animals in a herd undergoing a single examination, and the incidence reaches 68% within a year, given that some cows get reinfected more than once. The disease causes significant economic losses to dairy industry both in the Russian Federation and globally. Mastitis is an inflammation of the mammary gland that develops in response to the effects of various factors of the external and internal environment, which are classified as mechanical, physical, biological, etc. Based on the clinical symptoms, the disease has two forms: clinical and subclinical. Both the animal and its milk shall be subjected to a thorough examination for the diagnosis establishment. The final stage of the mastitis diagnosis in cows is laboratory testing. In this case, the most informative is the bacteriological method, which helps to isolate a pathogen’s pure culture, identify it and determine sensitivity to antimicrobial drugs. The latter plays a specific role in indicating the direction of further therapeutic measures, since the obtained data facilitate selection of effective antibiotics against certain pathogens. Incorrect treatment, incompliances with the prescribed therapy, as well as unnecessary use of antimicrobials can lead to the generation of multi-resistant bacteria. Due to the widespread spread of antibiotic-resistant microorganism strains, despite the large number of drugs currently used, their effectiveness is constantly decreasing. The prospects for the further use of antibiotics as therapeutics are questioned by many researchers and international organizations due to antibiotic resistance rapidly developing in many agents. Vaccination plays a significant role in infectious disease control. The use of vaccines not only reduces mastitis occurrence in cows, but also significantly improves the quality of dairy products.

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The combination of vaccines and adjuvants to prevent the occurrence of high incidence of infectious diseases in bovine

Yao,

Zhang,

Yang

2023

Front. Vet. Sci.

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As the global population grows, the demand for beef and dairy products is also increasing. The cattle industry is facing tremendous pressures and challenges. The expanding cattle industry has led to an increased risk of disease in cattle. These diseases not only cause economic losses but also pose threats to public health and safety. Hence, ensuring the health of cattle is crucial. Vaccination is one of the most economical and effective methods of preventing bovine infectious diseases. However, there are fewer comprehensive reviews of bovine vaccines available. In addition, the variable nature of bovine infectious diseases will result in weakened or even ineffective immune protection from existing vaccines. This shows that it is crucial to improve overall awareness of bovine vaccines. Adjuvants, which are crucial constituents of vaccines, have a significant role in enhancing vaccine response. This review aims to present the latest advances in bovine vaccines mainly including types of bovine vaccines, current status of development of commonly used vaccines, and vaccine adjuvants. In addition, this review highlights the main challenges and outstanding problems of bovine vaccines and adjuvants in the field of research and applications. This review provides a theoretical and practical basis for the eradication of global bovine infectious diseases.

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Novel Proteoliposome-Based Vaccine against E. coli: A Potential New Tool for the Control of Bovine Mastitis

Cited by 4 publications

References 97 publications

Advances in Diagnostic Approaches and Therapeutic Management in Bovine Mastitis

Advances in Diagnostic Approaches and Therapeutic Management in Bovine Mastitis

Etiology and epizootology of bovine mastitis (analytical review)

The combination of vaccines and adjuvants to prevent the occurrence of high incidence of infectious diseases in bovine

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