Novel protective effect of manganese against ferrous citrate-induced lipid peroxidation and nigrostriatal neurodegeneration in vivo

Sziráki, István; Rauhala, Pekka; Chiueh, Chuang C.

doi:10.1016/0006-8993(95)01056-2

Cited by 33 publications

(16 citation statements)

References 14 publications

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“…The potent effects of trace amounts of trivalent cations upon manganese-related free radical events may account for the discordant literature on this subject. Our findings can reconcile reports of inhibition of iron-based ROS production by manganese [40,7], and descriptions of the apparently intrinsic ROS-generating capacity of manganese in both divalent and trivalent forms [18]. The coexistence of both the divalent and trivalent forms of manganese in biological tissues underscores the potential metabolic significance of interactions of manganese in different valence states.…”

Section: Discussionsupporting

confidence: 89%

Modulation of oxidative events by multivalent manganese complexes in brain tissue

HaMai

Campbell

Bondy

2001

Free Radical Biology and Medicine

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Abstract-Manganese toxicity can evoke neuropsychiatric and neuromotor symptoms, which have frequently been attributed to profound oxidative stress in the dopaminergic system. However, the characterization of manganese as a pro-oxidant remains controversial because antioxidant properties also have been associated with this metal. The current study was designed to address these disparate findings concerning the oxidative properties of manganese. The apparent ability of manganese in its divalent form to promote formation of reactive oxygen species (ROS) within a cortical mitochondrial-synaptosomal (P2) fraction was completely abolished by the addition of one five hundredth of its molarity of desferroxamine (DFO), a trivalent metal chelator. This large ratio and the high specificity of DFO for trivalent metal ions discounted the possibility of inhibition of ROS generation by direct sequestration of divalent manganese, and implied the trace presence of a trivalent metal. Further analysis suggested that this trace metal was manganic rather than ferric ion. Ferric ion was able to dampen the reactive oxygen species-generating capacity of manganous chloride, whereas manganic ion markedly promoted this property attributed to manganous ion. Such findings of the potent effects of trace amounts of trivalent cations upon Mn 2ϩ -related free radical generation offer resolution of earlier disparate findings concerning the oxidative character of manganese.

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Section: Discussionsupporting

confidence: 89%

Modulation of oxidative events by multivalent manganese complexes in brain tissue

HaMai

Campbell

Bondy

2001

Free Radical Biology and Medicine

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“…Recent studies suggest that cell death induced by Mn may be caused by oxidative stress leading to apoptosis (Desole et al, 1996(Desole et al, , 1997aHirata et al, 1998;Schrantz et al, 1999). It is unclear as to the role oxidative stress in initiating apoptosis because current evidence indicates that Mn, unlike iron, is actually an antioxidant (Sziraki et al, 1995(Sziraki et al, , 1998(Sziraki et al, , 1999Talavera et al, 1999). Mn may stimulate apoptosis in rat pheochromocytoma (PC12) cells as evidenced by increased Tunel staining, internucleosomal DNA cleavage, and activation of the JNK pathway (Desole et al 1996(Desole et al , 1997aHirata et al, 1998).…”

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confidence: 99%

Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation

et al. 2000

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“…[25][26][27][28] High dose of manganese cause oxidative injury and low dose have antioxidant effect. 29,30 Manganese is of importance to avian metabolism as it is involved in the synthesis of choline and cholesterol. It has been reported to have hypoglycemic effect.…”

Section: Discussionmentioning

confidence: 99%

Determination of the inorganic composition and short term effect of aqueous extracts of root, pod, and stem of Telfairia occidentalis on some hematological parameters in rats

Ogbonnaya

Uadia

2016

Asian J Med Sci

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Aims and Objectives:This study is to investigate the inorganic composition and the effect of fourteen (14) -day oral administration of aqueous extracts of root, pod and stem of Telfairia occidentalis in rats.Materials and Methods: Plant samples were analyzed for K, P, Mg, Ca, S, Mn, Fe, Cu, Zn, Pb, and Crusing atomic absorption spectrophotometry (AAS). Wister rats of both sexes were assigned to sixteen (16) groups of 4 animals per group. Different animal groups received distilled water and root, stem, and pod extracts at the doses of 250, 750, 1500, 2250, and 3000mg/kg of body weight. All animals were treated for 14 days and sacrificed on the 15 th day. Results: The inorganic composition result showed that potassium (K) was the highest in abundance in all the samples (root, pod, and stem), compared to the other mineral elements. The root contained high levels of potassium and manganese; the stem had magnesium, manganese and iron while the pod contained high amount of potassium, manganese and iron. Hematological assay results showed reduction in the values of white blood cell (WBC) count for higher doses of root extract and all doses (except for 1500 mg/kg bw) of pod extract. Platelet count (PLT) was significantly high for root extract at 750 mg/kg bw. The stem extract showed a consistent decrease in the red blood cell (RBC) count for all dose administered. Conclusion: Telfairia occidentalis root, pod, and stem may be good sources of inorganic elements. The extracts have varying effects on hematological parameters which may be dosage-and duration-dependent.

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Novel protective effect of manganese against ferrous citrate-induced lipid peroxidation and nigrostriatal neurodegeneration in vivo

Cited by 33 publications

References 14 publications

Modulation of oxidative events by multivalent manganese complexes in brain tissue

Modulation of oxidative events by multivalent manganese complexes in brain tissue

Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation

Determination of the inorganic composition and short term effect of aqueous extracts of root, pod, and stem of Telfairia occidentalis on some hematological parameters in rats

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