Novel prospects of statins as therapeutic agents in cancer

Pisanti, Simona; Picardi, Paola; Ciaglia, Elena; Am, D'Alessandro; Bifulco, Maurizio

doi:10.1016/j.phrs.2014.06.013

Cited by 106 publications

(103 citation statements)

References 195 publications

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“…Among 610 patients with breast cancer, 83 (13.6%) were receiving a statin. Most frequently used regimens included atorvastatin (45 patients), simvastatin (19), pravastatin (eleven), rosuvastatin (six), and fluvastatin (two).…”

Section: Resultsmentioning

confidence: 99%

“…1,[10][11][12] Several preclinical studies have suggested a direct effect of these agents in certain cellular functions, including cell-cycle arrest and apoptosis, 13,14 cancer invasion and angiogenesis, 15,16 tumor differentiation or sensitization to chemotherapy, and cholesterol formation. [17][18][19] Several studies have found a reduced risk of developing various types of cancer, including breast cancer, in patients using statins. 1,[20][21][22][23] Benefit has recently been expanded to patients already diagnosed with cancer receiving statins compared to nonusers, showing reduced cancer-related mortality.…”

Section: Introductionmentioning

confidence: 99%

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Statins and risk of breast cancer recurrence.

Sakellakis

Kostaki

Akinosoglou

et al. 2016

JCO

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Background:The primary end point of our study was to test whether the concurrent use of a statin is related to a lower risk of recurrence and increased relapse-free survival in patients with early breast cancer. Materials and methods:We reviewed 610 female patients with stage I, II, or III breast cancer who had been surgically treated and who had subsequently received at least adjuvant chemotherapy in order to prevent recurrence. Results: Among the 610 patients with breast cancer, 83 (13.6%) were receiving a statin on a chronic basis for other medical purposes. Overall, statin users displayed longer mean relapsefree survival (16.6 vs 10.2 years, P=0.028). After data had been adjusted for patient and disease characteristics, statin users maintained a lower risk of recurrence. This favorable outcome in statin users was particularly evident when we included only younger patients in the analysis (20 vs 10 years, P=0.006). Conclusion: Statins may be linked to a favorable outcome in early breast cancer patients, especially in younger age-groups.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Statins and risk of breast cancer recurrence.

Sakellakis

Kostaki

Akinosoglou

et al. 2016

JCO

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“…Several aspects related to the pharmacological use of statins have recently been reviewed [1][2][3][4][5][6][7][8][9].…”

mentioning

confidence: 99%

No effects of atorvastatin (10mg/d or 80mg/d) on nitric oxide, prostacyclin, thromboxane and oxidative stress in type 2 diabetes mellitus patients of the DALI study

Tsikas

Pham

Suchy

et al. 2015

Pharmacological Research

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“…19 The age possibly influenced that dysplasia was the predominant pattern. 20 In our study, the rats were 4 months (young adults) which allows their tissues respond less aggressively. The histological pattern found in the rats given ethanol extract of Chuquiraga spinosa showed discrete dysplasia with fibrotic areas.…”

Section: Discussionmentioning

confidence: 99%

Chuquiraga spinosa Lessing: A Medicinal Plant for Gastric Cancer Induced By N-Methyl-N-Nitroso-Urea (NMU)

Arroyo-Acevedo

Herrera-Calderon²,

Rojas-Armas

et al. 2017

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Background: Gastric cancer (GC) is one of the most frequent diseases in human population: Many plants from Peruvian flora is used to treat cancer as alternative treatment. Chuquiraga spinosa Lessing (ChS) is a species with high potential therapeutic due to its antioxidant and anti-inflammatory effect as well as protective against prostate cancer. Objective: The main objective was to evaluate the possible protective effect of Chuquiraga spinosa extract on NMU (N-methyl-N nitrosourea)-induced gastric cancer in rats. Methods: Gastric carcinogenesis was induced in 30 male Holtzman rats by providing NMU 50 μg/Kg by oral administration for 16 weeks. Ethanolic extract of ChS aerial parts was administered at doses 50, 250 and 500 mg/Kg per oral. The protective effect was determined through weight controls, biochemical and hematological parameters; the antioxidant capacity by superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA) and anti-inflammatory capacity by the level of C-reactive protein (CRP). The tumors were monitored by using histological examinations. Results: Oral administration of Chuquiraga spinosa extract significantly decreased superoxide dismutase malondialdehyde, nitric oxide, C-reactive protein levels (p<0,01, p<0,01, p<0,01 and p<0,01 respectively compared with Inductor group). There was a significant increase in the weights of animals (P<0.05). Conclusion: Considering the anti-inflammatory, antioxidant, and anticancer properties of Chuquiraga spinosa extract, we conclude that it has a protective effect on NMU induced gastric cancer in rats. Many medicinal plants are used by patients with cancer due to numerous positive effects on pain relief, vomiting, nauseas, depression, and anxiety. 8Bioactive compounds such as polyphenols, tannins, flavonoids can have antioxidant capacity with potential benefits for health and could reduce cancer risk, it has been demonstrated that the anti-inflammatory effect of these compounds inhibit arachidonic acid (AA), prostaglandins, and leukotrienes.9 Polyphenols are chemoprotectives that act by blocking of initiation stage of carcinogenesis, free radicals and activation of glutathione peroxidase, glutathione reductase and inactivation of glutathione S transferase. 10Chuquiraga spinosa (ChS) Lessing (Family: Asteraceae) is called "huamanpinta" and is a species with therapeutic properties from Peruvian flora. The stem and leaves infusion of this plant is used for its antiinflammatory effects and urinary infections. Previous studies have reported that ChS presents anti-inflammatory and antimicrobial effects. 11 The main objective in this research was to determine the protective effect of aerial parts of Chuquiraga spinosa on NMU induced gastric cancer in rats. 21 MATERIALS AND METHODS AnimalsA total of 30 rats Holtzman (150 ± 20 g) of male sex were obtained from the National Institute of Health (Lima, Peru). Rats were kept in plastic cages with access to pelletized food and water ad libitum and housed in animal room with controlled temperature (2...

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Novel prospects of statins as therapeutic agents in cancer

Cited by 106 publications

References 195 publications

Statins and risk of breast cancer recurrence.

Statins and risk of breast cancer recurrence.

No effects of atorvastatin (10mg/d or 80mg/d) on nitric oxide, prostacyclin, thromboxane and oxidative stress in type 2 diabetes mellitus patients of the DALI study

Chuquiraga spinosa Lessing: A Medicinal Plant for Gastric Cancer Induced By N-Methyl-N-Nitroso-Urea (NMU)

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