Novel probes, carriers and prodrugs to target senescent cells in vivo

Abstract

Chapter 1|General introduction and interferents 5.10.24 Silencing and western blotting experiments of β-galactosidase 5.10.25 X-Gal staining of kidney, liver and tumors from BALB/cByJ female mice carrying orthotopic 4T1 mammary tumors with or without palbociclib treatment 5.10.26 Images of BALB/cByJ female mice bearing 4T1 mammary tumors treated with palbociclib and i.p. injected with Cy7Gal 5.10.27 Fluorophore biodistribution in BALB/cByJ mice bearing 4T1 mammary tumours treated with palbociclib and in the animal model of accelerated aging SAMP8 and its control SAMR1, after i.p. injection with Cy7Gal or WOS-Cy7Gal 5.10.28 Images of 2 and 14 months old BALB/cByJ female mice i.p. injected with Cy7Gal Chapter 6| Real time in vivo detection of cellular senescence through the controlled release of the NIR fluorescent dye Nile Blue 201-229