Novel Preparation Method of Hydroxyapatite Fibers

Abstract

A novel method for preparing calcium hydroxyapatite (Ca10(PO4)6(OH)2: HAp) fibers has been developed. HAp fibers can be prepared successfully by heating a compact consisting of calcium metaphosphate (ß‐Ca(PO3)2) fibers with Ca(OH)2 particles in air at 1000°C and subsequently treating the resultant compact with dilute aqueous HCl solution. The ß‐Ca(PO3)2 fibers and the Ca(OH)2 in the compact were converted into fibrous HAp and CaO phases by the heating, and the CaO phase was removed by acid‐leaching. HAp fibers obtained in the present work were 40‐150 µm in length and 2‐10 µm in diameter. The fibers had almost the same dimensions as those of the ß‐Ca(PO3)2 fibers.

Development of nanocomposites for bone grafting

“…The impact of nano-HA has also been extensively reviewed with regard to recently developed manufacturing techniques [26,13]. Some of the prominent processing methods for manufacturing nano-HA include solid state [58], wet chemical [59,60], hydrothermal [61,62], mechanochemical [63], pH shock wave [64], and microwave processing [65] (see Table 9). HA can also be processed from animal bone [66,67] and coral exo-skeleton [68,69] HA has a unique capability of binding to the natural bone through biochemical bonding, which promotes the interaction between host bone and grafted material.…”

Hydroxylapatite nanoparticles: fabrication methods and medical applications

“…CaHPO 4 + CaO [54], Ca 2 P 2 O 7 + CaO [55,56], β-Ca 3 (PO 4 ) 2 + CaO [57,58]) at a stoichiometric Ca/P mixing ratio for HAp formation at high temperatures (typically above 700…”

Development of Cell-Responsive Nanophase Hydroxyapatite for Tissue Engineering

“…The solid state reaction typically takes place at a very high temperature (~1000°C). A method for the preparation of HA fibers was introduced using a solid phase reaction [16] . With this method, the HA fibers were produced by heating a compact consisting of calcium metaphosphate fibers with calcium hydroxide particles at 1000°C in air, and treated subsequently with dilute aqueous HCl solution to remove unwanted secondary phase substitution such as CaO.…”

“…The nanophase HA is therefore perceived to be beneficial in bone tissue engineering as a new generation scaffolding system. There are several methods for the synthesis of nanophase HA, which include wet chemical [14,15] , solid state [16] , hydrothermal [17,18] , mechanochemical [19] , pH shock wave [20] , and microwave processing [21] .…”