Novel predictive risk factor for erectile dysfunction: Serum high‐sensitivity C‐reactive protein

Liu, Guodong; Zhang, Yuyang; Zhang, Wei; Wu, Xu; Jiang, Hui; Huang, Houbao; Zhang, Xiansheng

doi:10.1111/andr.13206

Cited by 9 publications

(7 citation statements)

References 67 publications

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“…Zhang et al performed a meta-analysis involving 7 relevant studies and identified NLR and PLR as independent risk factors for ED 8 . In addition, serum C-reactive protein-albumin ratio and serum high-sensitivity C-reactive protein have been associated with ED risk 7 , 24 . It is worthwhile emphasizing that PDE5i treatment can significantly reduce serum C-reactive protein levels 7 .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, serum C-reactive protein-albumin ratio and serum high-sensitivity C-reactive protein have been associated with ED risk 7 , 24 . It is worthwhile emphasizing that PDE5i treatment can significantly reduce serum C-reactive protein levels 7 . Hence, HALP can reliably predict the risk of ED.…”

Section: Discussionmentioning

confidence: 99%

“…Liu et al performed a meta-analysis involving 12 studies and found higher CRP levels in ED patients compared to healthy controls. Moreover, they described that PDE5I therapy can restore CRP levels 7 . In 2015, Chen et al proposed a prognostic score based on preoperative hemoglobin and albumin levels, as well as lymphocyte and platelet counts, and concluded that gastric cancer patients with a score higher than 56.8 had a more favorable prognosis 8 .…”

Section: Introductionmentioning

confidence: 99%

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Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study

Chen,

Zhou

et al. 2024

Sci Rep

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Erectile dysfunction (ED) is related to nutritional and inflammatory factors. The hemoglobin, albumin, lymphocyte, and platelet score (HALP), a new index reflecting the nutritional and inflammatory status, has been associated with a higher risk of diabetic retinopathy, particularly at lower values (≤ 42.9). However, studies focusing on the relationship between HALP and ED risk are scarce. Hence, this study aimed to investigate the association between HALP and ED. Data were extracted from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2004. Based on self-reported data, participants were classified into either the ED group or the non-ED group. Next, the HALP score was categorized into four quartiles (Q1–4). Weighted multivariate regression analysis was performed to assess the relationship between categorical HALP and ED risk. Additionally, restricted cubic spline (RCS) analysis was conducted to examine the association between continuous HALP scores and ED risk. Furthermore, subgroup analyses were conducted to examine the association between categorical HALP and the risk of ED based on age, as well as the status of hypertension, diabetes and cardiovascular disease. Finally, a mediation analysis was carried out to investigate the mediating effect of HALP and related parameters on the association between urinary cobalt levels and ED. Initially, the data of 21,161 participants were collected. After implementing the inclusion and exclusion criteria, 3406 participants were included in the final analyses. Weighted multivariate regression analysis demonstrated that the Q4 HALP group was associated with a lower risk of ED (OR 0.96, 95% confidence intervals 0.92–1.00, P = 0.037). Meanwhile, RCS analysis showed that HALP was nonlinearly associated with the risk of ED. In addition, subgroup analyses demonstrated that participants in the Q3/4 HALP group had a significantly lower ED risk than those in the Q1 group among patients aged ≥ 50 years, as well as those with hypertension and diabetes. Lastly, mediation analysis revealed that HALP and its associated parameters had a marginal average causal mediation effect on the relationship between urinary cobalt levels and ED risk (P > 0.05). In US adults, high HALP scores were correlated with a lower risk of ED. The relationship was more pronounced in participants aged ≥ 50 years with hypertension and diabetes. Furthermore, HALP and its parameters may not mediate the association between urinary cobalt levels and ED risk.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study

Chen,

Zhou

et al. 2024

Sci Rep

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“…Furthermore, a recent novel meta-analysis concluded that CRP is statistically significantly associated with erectile dysfunction and could possibly be a marker or a risk factor for the condition [ 446 ]. CRP has also been assessed on penile vascular disease where there can be a slight increase (mean approx.…”

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

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The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.

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“…Meanwhile, they found PDE5I therapy can improve the abnormal CRP levels. 9 Sembel et al performed a compare study including 101 ED patients and found a higher PLR, NLR and CRP than sexually active male. 2 Systemic immune‐inflammation index (SII), as a new integrated indicator based on peripheral blood lymphocytes, neutrophils, and platelets, was reported a relationship with hyperlipoidemia, cardiogenic shock, hypertension, and depression.…”

Section: Introductionmentioning

confidence: 99%

Association between the systemic immune‐inflammation index and erectile dysfunction: A cross‐sectional study

Chen,

Luo

et al. 2024

Immunity Inflam & Disease

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BackgroundErectile dysfunction (ED) is associated with inflammation. The systematic immune‐inflammation index (SII), as a new inflammation marker, was applied to predict the risk of diseases. However, no research explores the relationship between SII and ED. Hence, the purpose of this study was to investigate the association between SII and ED.MethodsRelated data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001−2004. Based on self‐report, all participants were classified into ED and non‐ED group. Weighted multivariate regression analysis the relationship between categorical SII and ED in unadjusted and adjusted models. Restricted cubic spline (RCS) was used to examine the association of continuous SII and ED risk. Furthermore, the association between categorical SII and the risk of ED was evaluated among subgroups of age, body mass index, hypertension, diabetes and cardiovascular disease. Finally, weighted multivariate regression analysis and RCS were performed to assessed the connection between SII and the risk of severe ED.ResultsInitially, data on 21,161 participants were obtained. After implementing the inclusion and exclusion criteria, 3436 participants were included in analyses. Weighted multivariate regression analysis demonstrated that Q4 group SII was associated with an increased risk of ED (OR = 1.03, 95% confidence intervals: 1.00−1.05, p = .03). RCS showed SII was nonlinearly associated with the risk of ED, and the inflection point of SII was at 485.530. In addition, subgroup analyses demonstrated that participants in the SII > 485.530 group had a higher ED risk than SII ≤ 485.530 group among subgroups of age ≥50, hypertension, and non‐diabetes. Weighted multivariate regression analysis and RCS found no relationship of SII and the risk of severe ED.ConclusionIn US adults, SII > 485.530 was correlated with an increased risk of ED. While, no significant association between SII and severe ED risk. Additional studies are required to support our results.

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Novel predictive risk factor for erectile dysfunction: Serum high‐sensitivity C‐reactive protein

Cited by 9 publications

References 67 publications

Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study

Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Association between the systemic immune‐inflammation index and erectile dysfunction: A cross‐sectional study

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