Novel porous graphene oxide and hydroxyapatite nanosheets-reinforced sodium alginate hybrid nanocomposites for medical applications

Xiong, Guangyao; Luo, Honglin; Zuo, Guifu; Ren, Kaijing; Wan, Yizao

doi:10.1016/j.matchar.2015.07.016

Cited by 52 publications

(25 citation statements)

References 51 publications

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“…Total porosity was measured by the liquid (ethanol) displacement method with a specific gravity bottle on the basis of Archimedes’ principle . The total porosity was calculated according to Equation :

Porosity (%) = \frac{\frac{W_{2} - W_{3} - W_{normals}}{ρ_{normale}}}{\frac{W_{1} - W_{3}}{ρ_{normale}}} \times 100 %

where W 1 is the weight of the specific gravity bottle filled with ethanol; W 2 is the weight of the specific gravity bottle containing ethanol and scaffolds; W 3 is the weight of the specific gravity bottle after subtracting the weight of the scaffold from W 2 ; W s is the initial known weight of the scaffold; and ρ e is the density of ethanol (0.8 g cm −3 ).…”

Section: Methodssupporting

confidence: 86%

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Submicrofiber‐Incorporated 3D Bacterial Cellulose Nanofibrous Scaffolds with Enhanced Cell Performance

Wan

Cui

Zhang

et al. 2018

Macro Materials & Eng

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Combining nanofibers with submicrofibers is an effective way to design morphologically biomimetic tissue engineering scaffolds that imitate natural fibrous extracellular matrix (ECM) with varying lengths from nano‐ to submicrometer scales. Herein, the preparation of ECM‐mimetic scaffolds by conjugating electrospun cellulose acetate (CA) submicrofibers with bacterial cellulose (BC) nanofibers via a facile and scalable dispersion freeze‐drying process is reported. The morphology, structure, mechanical properties, and cell behavior of the as‐prepared nano/submicrofibrous BC/CA scaffolds are assessed. It is found that that the nano/submicrofibrous BC/CA scaffolds have 3D porous network structure with larger pores than the bare BC scaffold. Although the BC/CA scaffolds show decreased mechanical properties and porosity than their BC counterparts, they exhibit improved cell behavior over the bare BC scaffold. Moreover, the submicrofibers enable cell infiltration into the scaffolds. This suggests that the coexistence of nano‐ and submicrometer fibers enhances the attachment and spreading of cells on the nano/submicrofibrous scaffolds. This novel nano/submicrofibrous scaffold has great potential in tissue engineering and regenerative medicine.

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Porosity (%) = \frac{\frac{W_{2} - W_{3} - W_{normals}}{ρ_{normale}}}{\frac{W_{1} - W_{3}}{ρ_{normale}}} \times 100 %

Section: Methodssupporting

confidence: 86%

“…Water uptake ability ( W A ) was measured following the method from our previous work . Briefly, the dried samples were weighed ( W 0 ) and then immersed in simulated body fluid (SBF) for 24 h to allow complete swelling.…”

Section: Methodssupporting

confidence: 86%

Submicrofiber‐Incorporated 3D Bacterial Cellulose Nanofibrous Scaffolds with Enhanced Cell Performance

Wan

Cui

Zhang

et al. 2018

Macro Materials & Eng

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“…The solution was prepared by mixing PBS solution and 1 mol/L citric acid solution (used to adjust the pH value). The concentration of the released Ca 2+ and F À in the immersion solution was measured at different time intervals (1,2,3,4,5,7,9,11,13, and 15 days) using an inductively coupled plasma atomic emission spectrometer (ICP-AES) (Perkin Elmer Optima 7300V, Perkin Elmer, Waltham, MA) and a fluorine selective electrode, respectively (MP519, Sanxin, Shanghai, China).…”

Section: Solubility Measurementsmentioning

confidence: 99%

“…For instance, GO/HA/sodium alginate (GO/HA/SA) nanocomposite scaffolds prepared by a facile solution mixture and the freeze drying method showed a significant enhancement in mechanical properties. Compared with HA/SA, the compressive strength and elastic modulus of GO/HA/SA composites increased by 23.2% and 28.3%, respectively, with the addition of 1 wt% GO . Zhang et al fabricated and characterized graphene nanosheets (GNs)/HA composites and reported the effect of GNs on the mechanical properties and in vitro biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…Compared with HA/ SA, the compressive strength and elastic modulus of GO/ HA/SA composites increased by 23.2% and 28.3%, respectively, with the addition of 1 wt% GO. 9 Zhang et al 10 fabricated and characterized graphene nanosheets (GNs)/HA composites and reported the effect of GNs on the mechanical properties and in vitro biocompatibility. Zhu et al 11 also prepared a composite of HA reinforced with GNs and investigated the effects of GNs on the mechanical and biological properties.…”

Section: Introductionmentioning

confidence: 99%

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Graphene oxide/fluorhydroxyapatite composites with enhanced chemical stability, mechanical, and biological properties for dental applications

Shi

Bai

et al. 2017

Int J Applied Ceramic Tech

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A novel graphene oxide‐based fluorhydroxyapatite (GO/FHA) composite is prepared using an in situ chemical synthesis method. The mechanical properties, chemical stability, in vitro bioactivity, and antibacterial properties of the as‐synthesized GO/FHA composites with different GO amounts are reported. The result shows that the mechanical properties of the composites are strongly dependent on the adding amount of GO. The result of chemical stability indicates that the substitution of fluorine (F) into the hydroxyapatite (HA) crystal has a positive effect on the dissolution resistance. The in vitro bioactivity assessment shows that the osteoblast proliferation and differentiation ability on GO/FHA composites are improved.

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Bio‐Applications of Graphene Composites: From Bench to Clinic

Omidi

Fathinia

Farahani

et al. 2016

Advanced 2D Materials

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Novel porous graphene oxide and hydroxyapatite nanosheets-reinforced sodium alginate hybrid nanocomposites for medical applications

Cited by 52 publications

References 51 publications

Submicrofiber‐Incorporated 3D Bacterial Cellulose Nanofibrous Scaffolds with Enhanced Cell Performance

Submicrofiber‐Incorporated 3D Bacterial Cellulose Nanofibrous Scaffolds with Enhanced Cell Performance

Graphene oxide/fluorhydroxyapatite composites with enhanced chemical stability, mechanical, and biological properties for dental applications

Bio‐Applications of Graphene Composites: From Bench to Clinic

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