Novel Porous Barium Titanate/Nano-bioactive Glass Composite with High Piezoelectric Coefficient for Bone Regeneration Applications

Saeidi, Babak; Derakhshandeh, Mohammad Reza; Chermahini, Mehdi Delshad; Doostmohammadi, Ali

doi:10.1007/s11665-020-05016-0

Cited by 18 publications

(10 citation statements)

References 35 publications

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“…Our findings unlock novel functionalities of piezoelectric materials for biomedical applications. These materials offer several advantages such as long-term delivery of therapeutic effects, no concern over the increased bacterial resistance to drugs, no leaching of the compounds, biocompatibility, 43 low cytotoxicity 44 (Supporting Information-11), and white coloring for aesthetics. Our work shows that a single compound can exert combined therapeutical effects and explored using a novel framework to show the effect of these functionalities on the bond strength of dental interfaces.…”

Section: Discussionmentioning

confidence: 99%

Multifunctional Dental Composite with Piezoelectric Nanofillers for Combined Antibacterial and Mineralization Effects

Montoya

Jain

Londoño

et al. 2021

ACS Appl. Mater. Interfaces

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After nearly seven decades of development, dental composite restorations continue to show limited clinical service. The triggering point for restoration failure is the degradation of the bond at the tooth–biomaterial interface from chemical, biological, and mechanical sources. Oral biofilms form at the bonded interfaces, producing enzymes and acids that demineralize hard tissues and damage the composite. Removing bacteria from bonded interfaces and remineralizing marginal gaps will increase restorations’ clinical service. To address this need, we propose for the first time the use of piezoelectric nanoparticles of barium titanate (BaTiO3) as a multifunctional bioactive filler in dental resin composites, offering combined antibacterial and (re)mineralization effects. In this work, we developed and characterized the properties of dental piezoelectric resin composites, including the degree of conversion and mechanical and physical properties, for restorative applications. Moreover, we evaluated the antibacterial and mineralization responses of piezoelectric composites in vitro. We observed a significant reduction in biofilm growth (up to 90%) and the formation of thick and dense layers of calcium phosphate minerals in piezoelectric composites compared to control groups. The antibacterial mechanism was also revealed. Additionally, we developed a unique approach evaluating the bond strength of dentin–adhesive–composite interfaces subjected to simultaneous attacks from bacteria and cyclic mechanical loading operating in synergy. Our innovative bioactive multifunctional composite provides an ideal technology for restorative applications using a single filler with combined long-lasting nonrechargeable antibacterial/remineralization effects.

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Section: Discussionmentioning

confidence: 99%

Multifunctional Dental Composite with Piezoelectric Nanofillers for Combined Antibacterial and Mineralization Effects

Montoya

Jain

Londoño

et al. 2021

ACS Appl. Mater. Interfaces

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“…Synthetic piezoelectric polymers, such as PVDF and its copolymers, PLLA, and PHA, possess the advantage over natural piezoelectric polymers in terms of design flexibility, mechanical strength, and impact resistance; nonetheless, they have relatively low piezoelectric coefficients are thus restricted in their capacity to reconstruct the physiological electrophysiological microenvironment for bone repair [38,39]. Piezoelectric ceramics, such as HAp (Ca 10 (PO 4 ) 6 (OH) 2 , HAp), barium titanate (BaTiO 3 , BT), and (K 0.5 Na 0.5 NbO 3 , KNN), with outstanding piezoelectricity, high mechanical performance, and elastic modulus close to native bone tissue, have attracted fast-rising attention in the field of BTE; nonetheless, their high brittleness and low damage tolerance restrict their processing flexibility and BTE applications to some extent [40][41][42]. By mimicking the organic and inorganic components of native bones, piezoelectric composites consist of polymers and ceramics to reveal a higher piezoelectric coefficient, and superior mechanical flexibility and stability for bone regeneration [43,44].…”

Section: Bio-piezoelectric Materials For Bone Regenerationmentioning

confidence: 99%

3D/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering

Chen

et al. 2023

Int. J. Extrem. Manuf.

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Piezoelectricity in native bones has been well recognized as the key factor in bone regeneration. Thus, bio-piezoelectric materials have gained substantial attention in repairing damaged bone by mimicking the tissue's electrical microenvironment (EM). However, traditional manufacturing strategies still encounter limitations in creating personalized bio-piezoelectric scaffolds, hindering their clinical applications. Three-dimensional (3D)/four-dimensional (4D) printing technology based on the principle of layer-by-layer forming and stacking of discrete materials has demonstrated outstanding advantages in fabricating bio-piezoelectric scaffolds in a more complex-shaped structure. Notably, 4D printing functionality-shifting bio-piezoelectric scaffolds can provide a time-dependent programmable tissue EM in response to external stimuli for bone regeneration. In this review, we first summarize the physicochemical properties of commonly used bio-piezoelectric materials (including polymers, ceramics, and their composites) and representative biological findings for bone regeneration. Then, we discuss the latest research advances in the 3D printing of bio-piezoelectric scaffolds in terms of feedstock selection, printing process, induction strategies, and potential applications. Besides, some related challenges such as feedstock scalability, printing resolution, stress-to-polarization conversion efficiency, and non-invasive induction ability after implantation have been put forward. Finally, we highlight the potential of shape/property/functionality-shifting smart 4D bio-piezoelectric scaffolds in bone tissue engineering. Taken together, this review emphasizes the appealing utility of 3D/4D printed biological piezoelectric scaffolds as next-generation bone tissue engineering implants.

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“…Therefore, combining a piezoelectric ceramic which causes autonomous stimulation of bone cells through bioelectric cues with a classical bioactive material that leads to rapid biomineralisation in the interface is quite promising. Recently, a research group led by Saeidi et al demonstrated the beneficial properties of a freeze-casted BaTiO 3 /BG composite scaffold with high cytocompatibility and high cell viability of up to 98% compared to the control group [ 50 ]. In another approach by Zhao et al the combination of a poly (vinylidene fluoride) (PVDF) membrane with electro-spun collagen fibres with incorporated microscale BG particles showed promising bone regenerative results both in vitro and in vivo [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

3D printing of piezoelectric and bioactive barium titanate-bioactive glass scaffolds for bone tissue engineering

Polley,

Distler,

Scheufler

et al. 2023

Materials Today Bio

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Novel Porous Barium Titanate/Nano-bioactive Glass Composite with High Piezoelectric Coefficient for Bone Regeneration Applications

Cited by 18 publications

References 35 publications

Multifunctional Dental Composite with Piezoelectric Nanofillers for Combined Antibacterial and Mineralization Effects

Multifunctional Dental Composite with Piezoelectric Nanofillers for Combined Antibacterial and Mineralization Effects

3D/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering

3D printing of piezoelectric and bioactive barium titanate-bioactive glass scaffolds for bone tissue engineering

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