Abstract:Stem cells play a pivotal role in lung homeostasis, repair, and regeneration, and yet the mechanisms underlying these processes are unknown. Furthermore, species-specific differences make certain findings from mice, a widely used animal model, difficult to translate into humans. In this work, we address these limitations by using a transgenic pig model and identify two populations of LGR5+ cells in the lung. Interestingly, we found similar populations in human lungs but not in mice. Using RNA sequencing, 3D im… Show more
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