Novel porcine model of Crohn's disease anastomotic stricture suitable for evaluation and training of advanced endoscopic techniques

The creation of in vivo animal models for stricture: a step in the right direction for training and advances in interventional inflammatory bowel disease

“…In their article, Lukas et al 7 describe the construction of an in vivo pig model of anastomotic strictures, mimicking CD strictures. The authors used miniature pigs for the study.…”

“…The authors performed endoscopy to measure the stricture every 2 months thereafter. 7 Of 19 pigs undergoing surgery, strictures successfully developed in 16 pigs. In 15 of these animals, 6-month follow-up was completed.…”

“…Interestingly, granulomas with occasional abscesses were also seen in some animals. 7 The presence of numerous eosinophils may suggest that those granulomas may represent a foreign body reaction.…”

“…The endoscopic intervention was successful, as measured by the passage of the endoscope. 7 Therefore, the authors not only demonstrated reliable techniques for the creation of anastomotic stricture in a large animal With the current footprint available, we should be able to replicate these in vivo models across academic centers. Cost still remains a factor, but future partnerships with industry to advance research models like these should be looked at more closely.…”

“…To advance the field of interventional IBD, it is imperative to train our future IBD specialists and advanced endoscopists in these techniques. By training on in vivo animal models like those described by Lukas et al, 7 the real-life conditions we encounter in patients can be mimicked. The trainee can also appreciate the sophisticated techniques involved while having the luxury of training in a nonstressful environment.…”