Novel polymersomes based on amphiphilic graft polyphosphazenes and their encapsulation of water-soluble anti-cancer drug

Cheng, Zheng; Qiu, Liyan; Zhu, K. J.

doi:10.1016/j.polymer.2009.01.004

Cited by 74 publications

(43 citation statements)

References 12 publications

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“…Zhang et al have synthesized and developed thermally sensitive amphiphilic phosphazenes for sustained local delivery [108,109]. They also synthesized methoxypoly(ethylene glycol) and ethyl-p-aminobenzoate side groups (PEG/EAB-PPPs) polyphosphazenes for delivery of water soluble anticancer agent like Doxorubicin HCl [110]. Some of the most important water-soluble polyphosphazenes such as poly[di(carboxylatophenoxy)phosphazene] (PCPP), poly[di(methoxyethoxyethoxy) phosphazene] (MEEP), and a number of others have been studied in pioneering works of H. Allcock and his coworkers [111,112].…”

Section: Polyphosphazenesmentioning

confidence: 99%

Water Soluble Polymers for Pharmaceutical Applications

2011

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Advances in polymer science have led to the development of novel drug delivery systems. Some polymers are obtained from natural resources and then chemically modified for various applications, while others are chemically synthesized and used. A large number of natural and synthetic polymers are available. In the present paper, only water soluble polymers are described. They have been explained in two categories (1) synthetic and (2) natural. Drug polymer conjugates, block copolymers, hydrogels and other water soluble drug polymer complexes have also been explained. The general properties and applications of different water soluble polymers in the formulation of different dosage forms, novel delivery systems and biomedical applications will be discussed.

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Section: Polyphosphazenesmentioning

confidence: 99%

Water Soluble Polymers for Pharmaceutical Applications

2011

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“…Poly(dichlorophosphazene) was synthesized by ring opening polymerization at 250 8C. [10] PEG 2000 (Fluka) was azeotropically distilled with benzene before use and aminoterminal PEG 2000 (NH 2 -PEG 2000 ) was prepared via a two-step protocol as illustrated in our previous works. [10] N,N-Diisopropylethylenediamine (DPA) was purchased from Alfa Aesar and was dried using a 4 Å molecular sieve.…”

Section: Experimental Partmentioning

confidence: 99%

“…[10] PEG 2000 (Fluka) was azeotropically distilled with benzene before use and aminoterminal PEG 2000 (NH 2 -PEG 2000 ) was prepared via a two-step protocol as illustrated in our previous works. [10] N,N-Diisopropylethylenediamine (DPA) was purchased from Alfa Aesar and was dried using a 4 Å molecular sieve. Dextran/fluorescein isothiocyanate (FITC, M w 3 000-5 000) and Nile red were purchased from Sigma and used without further purification.…”

Section: Experimental Partmentioning

confidence: 99%

“…The product, abbreviated as [NP(PEG) 0.2 (DPA) 1.8 ] n , was collected by precipitation in ether. Afterwards, the crude copolymer was purified by dissolvingprecipitation twice and dialysis against pure water for two days as previously described [10] . …”

Section: Synthesis Of Polymersmentioning

confidence: 99%

“…We previously reported the first example of polyphosphazene vesicle with spherical shape that can encapsulate water-soluble anti-cancer drug doxorubicin (Dox) hydrochloride [10] and improve its therapeutic effect against drug sensitive tumor cells (17 times lower IC 50 compared to the free drug). To be disappointed, however, the in vitro cytotoxicity evaluation of that polymeric system did not exhibit any positive actions on drug resistant tumor cells, which inspired us to envision that the incorporation of pH-responsive feature into these vesicles would further extend their drug delivery capabilities, especially to overcome drug resistance of malignant tumor cells by taking advantage of their intracellular drug release.…”

Section: Introductionmentioning

confidence: 99%

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Novel Polymeric Vesicles with pH‐Induced Deformation Character for Advanced Drug Delivery

Cheng

Yao

Qiu

2010

Macromolecular Bioscience

Self Cite

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pH-responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lipophilic and hydrophilic molecules. The pH-dependent structure change of vesicles was also observed by DLS and TEM. Dox-loaded vesicles exhibit a sharp pH-responsive drug release profile and dramatically enhance the cytotoxicity of Dox against Dox-resistant MCF-7/adr cells. These results suggest such vesicles based on pH-responsive polyphosphazene hold great potential for specific drug therapy.

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Applications of Biodegradable Polymers in the Encapsulation of Anticancer Metal Complexes

Redrado,

Xiao,

Upitak

et al. 2024

Adv Funct Materials

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Metal complexes have recently attracted a lot of attention, particularly as anticancer and antibacterial agents, owing to their versatile mechanisms and easily tunable characteristics. However, the application of such compounds in a medical context, especially in cancer treatment, has been hampered due to their limited solubility and stability in water and aqueous solutions, as well as a lack of selectivity. To address these limitations, several approaches have been developed to improve the targeted delivery of these compounds and their solubility. The first strategy involves the physical encapsulation of these metal complexes within carriers to facilitate controlled drug release. The second strategy involves covalently linking metal complexes to polymers, creating prodrugs that can be converted to active drugs at a more controllable rate. Despite the increasing variety of polymers available, the need to develop those able to be metabolized by the body, producing non‐toxic residues, remains crucial for effective treatment, particularly in the area of diseases such as cancer. In this perspective article, an overview of recent developments in the encapsulation of metal complexes using biodegradable polymers for cancer therapy is provided. It is specifically highlighting how the formed nanoparticles (NPs) enhance the selectivity and toxicity toward cancer cells compared to the parent metal complex, while simultaneously reducing the harmful side effects of traditional chemotherapies, opening the door for using them in combination therapies (PDT, PTT).

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Novel polymersomes based on amphiphilic graft polyphosphazenes and their encapsulation of water-soluble anti-cancer drug

Cited by 74 publications

References 12 publications

Water Soluble Polymers for Pharmaceutical Applications

Water Soluble Polymers for Pharmaceutical Applications

Novel Polymeric Vesicles with pH‐Induced Deformation Character for Advanced Drug Delivery

Applications of Biodegradable Polymers in the Encapsulation of Anticancer Metal Complexes

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