Novel polymeric dressing to the treatment of infected chronic wound

Garms, Bruna Cambraia; Borges, Felipe Azevedo; Barros, Natan Roberto de; Marcelino, M.; Leite, Marcel Nani; Arco, Marina Constante Del; Salvador, Sérgio Luiz de Souza; Pegorin, Giovana Sant’Ana; Oliveira, Kassandra Sussi Mustafé; Frade, Marco Andrey Cipriani; Herculano, Rondinelli Donizetti

doi:10.1007/s00253-019-09699-x

Cited by 28 publications

(15 citation statements)

References 58 publications

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“…Thus, although the grafted matrices had a higher drug content compared to the non‐grafted matrices, NRL‐ g ‐AAc and PCL‐ g ‐AAc release SBB in a shorter period than NRL‐ ng and PCL‐ ng , respectively. The drug release of all matrices obeys bi‐exponential first‐order release which is commonly observed for drug/natural product release from NRL 13,43 . The bi‐exponential first‐order release is described by Equation ) and the values of each parameter and the determination coefficient ( R 2 ) are listed in Table 2.…”

Section: Results and Discusionmentioning

confidence: 96%

“…PCL‐ g ‐AAc after PBS wash showed a band at 1,560 cm −1 , characteristic of the carboxylate (COO − ) from the acrylate 41,42 . The FTIR spectrum of NRL‐ ng is displayed in Figure 2 and shows the characteristic bands at 836 cm −1 (cis‐1,4‐isoprene) and at 2,970 cm −1 , representing the ‐CH stretch 43,44 . The FTIR spectrum of NRL‐ g ‐AAc presented a band at 1,706 cm −1 (carboxylic acid) and a broad band in the range of 2,000–3,600 cm −1 (COOH), indicating successful grafting.…”

Section: Results and Discusionmentioning

confidence: 99%

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Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment

Morise

Mutch

Garms

et al. 2020

J of Applied Polymer Sci

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Sialorrhea is a disorder which causes an increase in salivation. Scopolamine butylbromide (SBB) can be administrated to treat sialorrhea and its transdermal application minimizes the occurrence of side effects. This work compared SBB adsorption and release from two polymer matrices, polycaprolactone and natural rubber latex, as well as the matrices modified by gamma irradiation-induced graft copolymerization of acrylic acid (AAc). Grafting with AAc-introduced carboxylate groups onto the surface of the matrices evident from chemical analysis and resulted in increased hydrophilicity evident from contact angle measurements. SBB adsorbed to the matrices without changing its structure and for the AAc-grafted matrices this was governed by electrostatic interactions. Higher SBB loading was observed for the AAc-grafted matrices while SBB release was slower for the nongrafted matrices than the grafted matrices. The four different matrices produced are candidates for the development of a transdermal drug delivery system.

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Section: Results and Discusionmentioning

confidence: 96%

Section: Results and Discusionmentioning

confidence: 99%

Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment

Morise

Mutch

Garms

et al. 2020

J of Applied Polymer Sci

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“…Various Gram-positive, Gram-negative, aerobic, and anaerobic bacteria as well as different species of fungi have been isolated from skin infections [17,20]. The most common bacterial pathogens implicated in wound infections include Staphylococcus aureus, Enterococcus spp., Streptococcus pyogenes, Escherichia coli, and Pseudomonas aeruginosa [15,21,22]. Other bacteria include Klebsiella pneumoniae, Acinetobacter spp., and Enterobacter spp.…”

Section: Bacterial Infection Of Woundsmentioning

confidence: 99%

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

et al. 2020

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The epidermal skin barrier protects the body from a host of daily challenges, providing protection against mechanical insults and the absorption of chemicals and xenobiotics. In addition to the physical barrier, the epidermis also presents an innate defense against microbial overgrowth. This is achieved through the presence of a diverse collection of microorganisms on the skin (the “microbiota”) that maintain a delicate balance with the host and play a significant role in overall human health. When the skin is wounded, the local tissue with a compromised barrier can become colonized and ultimately infected if bacterial growth overcomes the host response. Wound infections present an immense burden in healthcare costs and decreased quality of life for patients, and treatment becomes increasingly important because of the negative impact that infection has on slowing the rate of wound healing. In this review, we discuss specific challenges of treating wound infections and the advances in drug delivery platforms and formulations that are under development to improve topical delivery of antimicrobial treatments.

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“…Thus, it was observed that standard L929 cells did not differ from the ASDC isolated in this study. The prospects of performing autologous ADSCs grafts in burns associated with the topical use of a potent antimicrobial, anti-inflammatory and regenerating agent based on RP extracts 79 could be advantageous with occlusive dressings with natural latex rubber 46,80 .…”

Section: Indirect Mtt Cytotoxic Assaysmentioning

confidence: 99%

Natural Rubber Films Incorporated with Red Propolis and Silver Nanoparticles Aimed for Occlusive Dressing Application

et al. 2021

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In this work, NRL films were enriched with red propolis and silver nanoparticles with the aim of obtaining dressings with bactericide properties. To improve the properties of these materials, plasma treatment was also applied to the films. Cytotoxic effects were evaluated by MTT and agar diffusion assays on secondary and stem cells. Determination of cell behavior on the films were assessed by EDS and FEG-SEM. In general, the plasma modified NRL films presented hydrophilic character, favorable condition for biomedical applications. RBS results showed that silver is probably in nanoparticulate form. MTT assays revealed that non-cytotoxic effects were observed for all the samples extracts. Either the plasma treatment or silver deposition were effective in sterilizing the samples and modifying their surfaces. It was demonstrated in this in vitro study that ADSCs associated with NRL films enriched with propolis should be considered promising for application in the healing of occlusive wounds.

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Novel polymeric dressing to the treatment of infected chronic wound

Cited by 28 publications

References 58 publications

Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment

Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

Natural Rubber Films Incorporated with Red Propolis and Silver Nanoparticles Aimed for Occlusive Dressing Application

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