Novel Poly(vinyl alcohol)/Chitosan/Modified Graphene Oxide Biocomposite for Wound Dressing Application

Abstract

Rapid absorption of wound exudate and prevention of wound infection are prerequisites for wound dressing to accelerate wound healing. In this study, a novel kind of promising wound dressing is developed by incorporating polyhexamethylene guanidine (PHMG)‐modified graphene oxide (mGO) into the poly(vinyl alcohol)/chitosan (PVA/CS) matrix, conferring the dressing the required mechanical properties, higher water vapor transmission rate (WVTR), less swelling time, improved antibacterial activity, and more cell proliferation compared to the PVA/CS film crosslinked by genipin. In vivo experiments indicate that the PVA/CS/mGO composite film can accelerate wound healing via enhancement of the re‐epithelialization. PVA/CS/mGO composite film with 0.5 wt% mGO sheets displays the best wound healing properties, as manifested by the 50% higher antibacterial rate compared to GO and the wound healing rate of the mouse using this dressing is about 41% faster than the control group and 31% faster than the pure PVA/CS dressing. The underlying mechanism of the accelerated wound healing properties may be a result of the improved antibacterial ability to eradicate pathogenic bacteria on the wound area and maintain an appropriate moist aseptic wound healing environment to accelerate re‐epithelialization. These findings suggest that this novel composite PVA/CS/mGO film may have promising applications in wound dressing.

Designing Robust, Breathable, and Antibacterial Multifunctional Porous Membranes by a Nanofluids Templated Strategy

“…[36] In the meantime, the comparison of antibacterial activity and mechanical properties among CPTifs membrane and other porous CP-based polymer membranes are summarized in Table S1 (Supporting Information). Obviously, the tensile strength (TS) ratio of PCPTifs-1.5 to pure CP reported in our study was higher than the values reported previously (Figure 4a), [21,29,34,35] demonstrating that PCPTifs-1.5 membrane has both excellent antibacterial activity and mechanical properties. Previous studies have shown that the antibacterial activity of the CP membrane is mainly due to the surface charge of chitosan itself and not due to any antibacterial activity of PVA.…”

“…© 2020 Wiley-VCH GmbH for S. aureus), [34] CP/mGO membrane (80.32% for S. aureus and 77.33% for E. coli), [35] and was comparable to the activity of CP/ZnO bulk material (99.7% for S. aureus and 99.2% for E. coli). [36] In the meantime, the comparison of antibacterial activity and mechanical properties among CPTifs membrane and other porous CP-based polymer membranes are summarized in Table S1 (Supporting Information).…”

“…Based on the above results, the antibacterial activities of the PCPTifs‐1.5 membrane against E. coli and S. aureus were 98.5 ± 3.21% and 99.99 ± 1.35%, respectively. Obviously, the antibacterial activity of the PCPTifs‐1.5 membrane was superior to that of the CP samples ( * р < 0.05), such as CP nanofiber mats (84.56% for E. coli ), [ 28 ] porous methylcellulose (MCC)/CP ( E. coli for 81.2% and S. aureus for 15.1%), [ 29 ] CP/TiO 2 nanofibers (85% for E. coli and 90% for S. aureus ), [ 30 ] CP/sericin nanofibrous mat (0% for E. coli and 79.3% for S. aureus ), [ 31 ] lysozyme‐CLEA immobilized CP nanofibers (82.4% for S. aureus ), [ 32 ] CP nanofibrous membranes (75.5% for S. aureus and 83.6% for E. coli ), CP membrane (83.6% for E. coli and 75.5% for S. aureus ), [ 33 ] porous CP blend membrane (94.8% for E. coli and 91.3% for S. aureus ), [ 21 ] CP/bentonite/anthocyanin films (75.20% for E. coli and 44.38% for S. aureus ), [ 34 ] CP/mGO membrane (80.32% for S. aureus and 77.33% for E. coli ), [ 35 ] and was comparable to the activity of CP/ZnO bulk material (99.7% for S. aureus and 99.2% for E. coli ). [ 36 ] In the meantime, the comparison of antibacterial activity and mechanical properties among CPTifs membrane and other porous CP‐based polymer membranes are summarized in Table S1 (Supporting Information).…”

“…Water uptake was estimated using a weighed membrane that had previously been immersed in deionized water. Then, this membrane was carefully blotted with a filter paper and weighed after 5,10,15,25,35,45,60,75, and 90 min. For testing the tensility, the prepared membranes were cut into 20 mm wide samples.…”

Bio‐Derived Natural Materials Based Triboelectric Devices for Self‐Powered Ubiquitous Wearable and Implantable Intelligent Devices

“…[174] Chitin and chitosan can also be used for wound treatment because of their excellent adhesive, anti-bactericidal, and antifungal characteristics. [98,[175][176][177] Recently, chitin and chitosan have also been incorporated as the triboelectric materials in the triboelectric devices to realize cost-effective biodegradable mechanical energy harvesting. [12,35,41,91] Moreover, chitin and chitosan are effective biosorbents for effectively removing aquatic pollutants (e.g., heavy metal ions, organic dyes) in wastewater, owning to the high contents of hydroxyl and amino functional groups in chitin and chitosan.…”