Novel Poly(NIPA-<i>co</i>-AAc) Functional Hydrogels with Potential Application in Drug Controlled Release

Cuggino, Julio César; Contreras, Cintia Belén; Jiménez-Kairuz, Álvaro F.; Maletto, Belkys A.; Igarzabal, Cecilia Inés Álvarez

doi:10.1021/mp400615n

Cited by 40 publications

(28 citation statements)

References 34 publications

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“…Ofloxacin is a zwitherionic molecule which is more soluble in acidic pH and slightly soluble at neutral or alkaline pH conditions (intestinal environment) and it has chosen as a model of basic drug due to the presence of ionizable ternary piperazine amine group with capacities of acid-base interaction with the carboxylic groups of our synthesized polymer. It is known that such interaction yields a high degree of ionic pairs between a drug and a polyelectrolyte, acting as a drug reservoir [25].…”

Section: Introductionmentioning

confidence: 99%

Laser-assisted triggered-drug release from silver nanoparticles-grafted dual-responsive polymer

Amoli‐Diva

Sadighi‐Bonabi

Pourghazi³

2017

Materials Science and Engineering: C

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Laser assisted drug release from a synthesized plain polymer composed of poly (butyl methacrylate-co-acrylamide-co-methacrylic acid) [P(BMA-co-AAm-co-MAA)] and a metallo-polymer composed of silver nanoparticles (Ag NPs) grafted plain polymer (the nanocomposite) were studied to investigate their capability to serve as drug carriers. Positive temperature dependent swelling changes were observed for both carriers and their thermal sensitivity and thermal and optical switching properties were investigated in two buffered solutions. An acidic solution with pH=1.2 to simulate stomach body condition and a neutral solution with pH=7.4 to simulate intestine condition. Reversible phase transition (collapsing/swelling) with fast response time in the order of few seconds were observed by applying heat or by applying light radiation at the surface plasmon resonance wavelength of the attached NPs. Finally, cumulative release (%) of ofloxacin antibiotic as a model drug was investigated for both thermal and optical switching conditions. Based on these results, pulsatile release was observed which have the "on" and "off" states at higher and lower temperatures with respect to their volume-phase transition temperatures respectively.

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Section: Introductionmentioning

confidence: 99%

Laser-assisted triggered-drug release from silver nanoparticles-grafted dual-responsive polymer

Amoli‐Diva

Sadighi‐Bonabi

Pourghazi³

2017

Materials Science and Engineering: C

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“…Since temperature is a highly important parameter in the mammalian body, temperaturesensitive hydrogels have become the most investigated smart polymers [2][3]. The majority of thermosensitive hydrogels investigated in the past decades are synthetic polymers based on poly(N-isopropylacrylamide) (PNIPA) [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…The majority of thermosensitive hydrogels investigated in the past decades are synthetic polymers based on poly(N-isopropylacrylamide) (PNIPA) [2][3][4]. PNIPA hydrogels exhibit a non-linear volume phase transition (VPT) at a lower critical solution temperature (LCST) around 34 °C, which is close to the natural temperature of the human body [3,5].…”

Section: Introductionmentioning

confidence: 99%

Interactions in aromatic probe molecule loaded poly(N-isopropylacrylamide) hydrogels and implications for drug delivery

Manek

Domján

Madarász

et al. 2015

European Polymer Journal

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Small aromatic molecules are known to interact with poly(N-isopropylacrylamide) (PNIPA) based hydrogels, one of the most frequently employed polymers in temperature induced drug delivery systems. These interactions are poorly understood at the molecular level. In this article we investigate PNIPA both at the macroscopic and at the molecular level using measurements of swelling, differential scanning microcalorimetry (DSC), X-ray powder diffraction (XRD) and solid state 1 H NMR methods. The nature and the strength of the interactions affect the efficiency and kinetics of drug delivery. Phenols exert a major influence on PNIPA by reducing its phase transition temperature. The effect depends linearly on the phenol concentration, and is influenced also by the number of phenolic OH groups, as well as their relative positions. The strong interaction between phenol and the polymer that is detected by NMR hinders the crystallisation of phenol when the water is gradually evaporated. The aminoethyl phenol derivative dopamine has a much more limited effect, but in the opposite direction -the transition temperature increases slightly. The strong interaction observed among the dopamine molecules disables the polymer -dopamine interaction and favours crystallization of the dopamine when water is removed. These results reveal that embedding the drugs into polymer matrices for controlled delivery can alter the crystallinity of the stored molecules. As morphology is one of the crucial factors in delivery, this may compromise the rate and the efficiency of release.

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“…Among hydrogels, poly( N ‐isopropyl acrylamide) (PNIPA) gels have been extensively studied in the last few decades because of their interesting thermoresponsive properties. PNIPA gels exhibit a volume phase‐transition temperature (VPTT) in aqueous solution at about 32°C . Below its VPTT, PNIPA is hydrophilic, where the chains exist in coiled conformation and absorb a large amount of water.…”

Section: Introductionmentioning

confidence: 99%

Improved swelling–deswelling behavior of poly(N‐isopropyl acrylamide) gels with poly(N,N′‐dimethyl aminoethyl methacrylate) grafts

Dutta

Dhara

2015

J of Applied Polymer Sci

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Thermoresponsive and pH-responsive gels were synthesized from N-isopropyl acrylamide (NIPA) and N,N 0 -dimethyl aminoethyl methacrylate (DMAEMA) monomers. Gelation reactions were carried out with both conventional free-radical polymerization (CFRP) and controlled free-radical polymerization [reversible addition fragmentation transfer (RAFT)] techniques. The CFRP gels were prepared by polymerizing mixtures of NIPA and DMAEMA in 1,4-dioxane in presence of N,N'-methylene bisacrylamide (BIS) as cross-linker. The RAFT gels were prepared by a the polymerization of NIPA via a similar process in the presence of different amounts of poly(N,N 0 -dimethyl aminoethyl methacrylate) macro chain-transfer agent and the crosslinker. These gels were characterized by scanning electron microscopy (SEM) and differential scanning calorimetry. SEM analysis revealed a macroporous network structure for the RAFT gels, whereas their volume phase-transition temperatures (VPTTs) were found to be in the range 32-348C, close to that of poly(N-isopropyl acrylamide) gels. However, the CFRP copolymer gels exhibited a higher VPTT; this increased with increasing DMAEMA content. The RAFT gels exhibited higher swelling capabilities than the corresponding CFRP gels and also showed faster shrinking-reswelling behavior in response to changes in temperature. All of the gels showed interesting pH-responsive behavior as well. The unique structural attributes exhibited by the RAFT gels can potentially open up opportunities for developing new materials for various applications, for example, as adsorbents or carrier of drugs or biomolecules.

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Novel Poly(NIPA-co-AAc) Functional Hydrogels with Potential Application in Drug Controlled Release

Cited by 40 publications

References 34 publications

Laser-assisted triggered-drug release from silver nanoparticles-grafted dual-responsive polymer

Laser-assisted triggered-drug release from silver nanoparticles-grafted dual-responsive polymer

Interactions in aromatic probe molecule loaded poly(N-isopropylacrylamide) hydrogels and implications for drug delivery

Improved swelling–deswelling behavior of poly(N‐isopropyl acrylamide) gels with poly(N,N′‐dimethyl aminoethyl methacrylate) grafts

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