Abstract:Glycoprotein (GP)VI is the major platelet collagen receptor and a promising antithrombotic target. This was first demonstrated in mice using the rat monoclonal antibody JAQ1, which completely blocks the collagen-related peptide (CRP)-binding site on mouse GPVI and efficiently inhibits mouse platelet adhesion, activation and aggregation on collagen. Here, we show for the first time that JAQ1 cross-reacts with human GPVI (huGPVI), but not with GPVI in other tested species, including rat, rabbit, guinea pig, swin… Show more
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