Novel Picornavirus in Turkey Poults with Hepatitis, California, USA

Honkavuori, Kirsi S.; Shivaprasad, H. L.; Briese, Thomas; Street, Craig; Hirschberg, David L.; Hutchison, Stephen; Lipkin, W. Ian

doi:10.3201/eid1703.101410

Cited by 65 publications

(60 citation statements)

References 26 publications

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“…2). At nt positions 558 to 620 (domain J), 559 to 613 (domain J), 559 to 613 (domain J), and 672 to 702 (domain L and the 3=-end pyrimidine-rich region) OHuV-1 had 84%, 84%, 86%, and 100% nucleotide identity to Ljungan virus 1 (EF202833), foot-and-mouth disease virus SAT 1 (HM067706), bovine rhinitis A virus 2 (JN936206), and human cosavirus B1 (FJ438907) (3,12,14). The apical 22 nucleotides in domain D of hungaroviruses are completely identical to Ljungan virus 4 (EU854568) nt 2 to 23 (Fig.…”

Section: Figmentioning

confidence: 99%

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Two Closely Related Novel Picornaviruses in Cattle and Sheep in Hungary from 2008 to 2009, Proposed as Members of a New Genus in the Family Picornaviridae

Reuter

Pankovics

Knowles

et al. 2012

J Virol

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Section: Figmentioning

confidence: 99%

“…In the last few years, there has been a surge in the number of novel picornaviruses discovered and genomes sequenced (4,13,14,15,17,23,33). In 2008, a novel picornavirus (porcine kobuvirus) was serendipitously identified by our laboratory from domestic pigs (25).…”

mentioning

confidence: 99%

Two Closely Related Novel Picornaviruses in Cattle and Sheep in Hungary from 2008 to 2009, Proposed as Members of a New Genus in the Family Picornaviridae

Reuter

Pankovics

Knowles

et al. 2012

J Virol

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“…They bind directly to the ribosome and mediate initiation without the involvement of eukaryotic initiation factors (eIFs) (61,88). The second IRES class is epitomized by the ϳ330-nt-long IRESs of hepatitis C virus (HCV) and pestiviruses (designated HP) (47) and includes structurally related HPlike IRESs that occur in numerous picornaviruses, including porcine kobuvirus (PKV), a member of the Kobuvirus genus, members of the Teschovirus, Sapelovirus, Senecavirus, Tremovirus, and Avihepatovirus genera of Picornaviridae, seal picornavirus 1, and turkey hepatitis virus (8,14,21,26,35,37,73). The presence of related IRESs in unrelated viruses suggests that these elements have been exchanged by recombination (21).…”

mentioning

confidence: 99%

A Distinct Class of Internal Ribosomal Entry Site in Members of the Kobuvirus and Proposed Salivirus and Paraturdivirus Genera of the Picornaviridae

Sweeney

Dhote

et al. 2012

J Virol

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The 5=-untranslated regions (5= UTRs) of picornavirus genomes contain an internal ribosomal entry site (IRES) that promotes the end-independent initiation of translation. Picornavirus IRESs are classified into four structurally distinct groups, each with different initiation factor requirements. Here, we identify a fifth IRES class in members of Kobuvirus, Salivirus, and Paraturdivirus genera of Picornaviridae: Aichi virus (AV), bovine kobuvirus (BKV), canine kobuvirus (CKoV), mouse kobuvirus (MKoV), sheep kobuvirus (SKV), salivirus A (SV-A), turdivirus 2 (TV2), and TV3. The 410-nucleotide (nt)-long AV IRES comprises four domains (I to L), including a hairpin (L) that overlaps a Yn-Xm-AUG (pyrimidine tract/spacer/initiation codon) motif. SV-A, CKoV, and MKoV also contain these four domains, whereas BKV, SKV, and TV2/TV3 5= UTRs contain domains that are related to domain I and equivalent to domains J and K but lack an AV-like domain L. These IRESs are located at different relative positions between a conserved 5=-terminal origin of replication and divergent coding sequences. Elements in these IRESs also occur elsewhere: domain J's apical subdomain, which contains a GNRA tetraloop, matches an element in type 1 IRESs, and eIF4G-binding motifs in domain K and in type 2 IRESs are identical. Other elements are unique, and their presence leads to unique initiation factor requirements. In vitro reconstitution experiments showed that like AV, but in contrast to other currently characterized IRESs, SV-A requires the DExH-box protein DHX29 during initiation, which likely ensures that the initiation codon sequestered in domain L is properly accommodated in the ribosomal mRNA-binding cleft.

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“…Honkavuori et al (2008) discovered two strains of a novel Borna viruses in psittacine birds with proventriculus dilatation syndrome (PDS) characterised by gastrointestinal dysfunction and neurological signs. To identify a candidate of etiologic agent for turkey viral hepatitis (TVH), Honkavuori et al (2011) reported picornavirus in liver samples from diseased turkey poults. Fulminating disease (X disease) of guinea fowl is acute enteritis characterised by intense prostration and a very high mortality.…”

Section: Virus Discovery and Viral Metagenomicsmentioning

confidence: 99%

Next generation sequencing technologies: Tool to study avian virus diversity

Kapgate¹,

Barbuddhe²,

Kumanan³

2015

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Summary. -Increased globalisation, climatic changes and wildlife-livestock interface led to emergence of novel viral pathogens or zoonoses that have become serious concern to avian, animal and human health. High biodiversity and bird migration facilitate spread of the pathogen and provide reservoirs for emerging infectious diseases. Current classical diagnostic methods designed to be virus-specific or aim to be limited to group of viral agents, hinder identifying of novel viruses or viral variants. Recently developed approaches of next-generation sequencing (NGS) provide culture-independent methods that are useful for understanding viral diversity and discovery of novel virus, thereby enabling a better diagnosis and disease control. This review discusses the different possible steps of a NGS study utilizing sequence-independent amplification, high-throughput sequencing and bioinformatics approaches to identify novel avian viruses and their diversity. NGS lead to the identification of a wide range of new viruses such as picobirnavirus, picornavirus, orthoreovirus and avian gamma coronavirus associated with fulminating disease in guinea fowl and is also used in describing viral diversity among avian species. The review also briefly discusses areas of viral-host interaction and disease associated causalities with newly identified avian viruses.

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Novel Picornavirus in Turkey Poults with Hepatitis, California, USA

Cited by 65 publications

References 26 publications

Two Closely Related Novel Picornaviruses in Cattle and Sheep in Hungary from 2008 to 2009, Proposed as Members of a New Genus in the Family Picornaviridae

Two Closely Related Novel Picornaviruses in Cattle and Sheep in Hungary from 2008 to 2009, Proposed as Members of a New Genus in the Family Picornaviridae

A Distinct Class of Internal Ribosomal Entry Site in Members of the Kobuvirus and Proposed Salivirus and Paraturdivirus Genera of the Picornaviridae

Next generation sequencing technologies: Tool to study avian virus diversity

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