Novel phytonutrient contributors to antioxidant protection against cardiovascular disease

Riccioni, Graziano; Speranza, Lorenza; Pesce, Mirko; Cusenza, Salvatore; D’Orazio, Nicolantonio; Glade, Michael J.

doi:10.1016/j.nut.2011.11.028

Cited by 68 publications

(53 citation statements)

References 85 publications

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“…Previous studies have described many health-beneficial effects of each bioactive compound (selenium in organic form, quercetin, curcumin, catechins) present in cereal SOB (47). Selenium up-regulates the major component of the antioxidant defense mechanism by controlling the GSH pool and some antioxidative enzymes (48).…”

Section: Discussionmentioning

confidence: 99%

Impact of ovariectomy, high fat diet, and lifestyle modifications on oxidative/antioxidative status in the rat liver

et al. 2014

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AimTo estimate the impact of high fat diet and estrogen deficiency on the oxidative and antioxidative status in the liver of the ovariectomized rats, as well as the ameliorating effect of physical activity or consumption of functional food containing bioactive compounds with antioxidative properties on oxidative damage in the rat liver.MethodsThe study was conducted from November 2012 to April 2013. Liver oxidative damage was determined by lipid peroxidation levels expressed in terms of thiobarbituric acid reactive substances (TBARS), while liver antioxidative status was determined by catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR) activities, and glutathione (GSH) content. Sixty-four female Wistar rats were divided into eight groups: sham operated and ovariectomized rats that received either standard diet, high fat diet, or high fat diet supplemented with cereal selenized onion biscuits or high fat diet together with introduction of physical exercise of animals.ResultsHigh fat diet significantly increased TBARS content in the liver compared to standard diet (P = 0.032, P = 0.030). Furthermore, high fat diet decreased the activities of CAT, GR, and GST, as well as the content of GSH (P < 0.050). GPx activity remained unchanged in all groups. Physical activity and consumption of cereal selenized onion biscuits showed protective effect through increased GR activity in sham operated rats (P = 0.026, P = 0.009), while in ovariectomized group CAT activity was increased (P = 0.018) in rats that received cereal selenized onion biscuits.ConclusionFeeding rats with high fat diet was accompanied by decreased antioxidative enzyme activities and increased lipid peroxidation. Bioactive compounds of cereal selenized onion biscuits showed potential to attenuate the adverse impact of high fat diet on antioxidative status.

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Section: Discussionmentioning

confidence: 99%

Impact of ovariectomy, high fat diet, and lifestyle modifications on oxidative/antioxidative status in the rat liver

et al. 2014

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“…8 These "natural substances" are low-molecular weight organic compounds found in plants that activate a defence system against physiological and/or environmental stress. [9][10][11] Such compounds have antioxidant, antimicrobial, and immunomodulatory properties and derive from secondary metabolites, which belong mainly to the category of terpenes, terpenoids, alkaloids, phenols, and flavonoids. [12][13][14] Polyphenols compound are secondary metabolites widely distributed in the plant kingdom, with many biological properties, antiallergic, antiatherogenic, anti-inflammatory, antimicrobial, and antioxidant.…”

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confidence: 99%

Efficacy of a Solution Composed by Verbascoside, Polyvinylpyrrolidone (PVP) and Sodium Hyaluronate in the Treatment of Chemotherapy-induced Oral Mucositis in Children With Acute Lymphoblastic Leukemia

Bardellini

Amadori

Schumacher

et al. 2016

Journal of Pediatric Hematology/Oncology

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Summary: The aim of this study was to assess the efficacy of a solution composed by verbascoside, polyvinylpyrrolidone, and sodium hyaluronate (Mucosyte) in the treatment of chemotherapyinduced oral mucositi (OM). Patients between 5 and 18 years receiving chemotherapy for acute lymphoblastic leukemia and with OM grade 1 or 2 were randomized in group A (treated with Mucosyte, 3 mouthwashes/d per 8 d) and group B (treated with placebo, ie, an inert water-based solution, 3 mouthwashes/d per 8 d). The OM scoring was performed at day 1 (diagnosis of OM-T0), after 3 days of treatment (T1), and at day 8 (T2). Pain was evaluated through the visual analog scale with the same timing of OM measurement. A total of 56 patients were included (28 patients per group). Group A experienced a statistically significant decline of OM at T2 (P = 0.0038); a statistically significant difference in pain reduction between 2 groups both at T1 and at T2 (P < 0.005) was observed. The use of Mucosyte mouthwashes in children with chemotherapy-induced OM may be recommended as supportive therapy.

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“…For example, an ex vivo study found that the flavonoids fisetin and tricetin greatly attenuated LPS-induced increases in concentrations of TNF-α in COPD patient blood and IL-6 in type 2 diabetes patient blood by targeting poly (ADP-ribose) polymerase, an essential element in upregulating pro-inflammatory cytokines [27]. Another class of molecules with broad anti-inflammatory effects in the Healthycell dietary supplement are carotenoids [25,30,38,39]. Similar to phenolic compounds, carotenoids indirectly attenuate pro-inflammatory cytokines by their direct action on NF-κβ, an activator of many pro-inflammatory genes including those encoding inducible nitric oxide synthase, cyclooxygenase-2, TNF-α, IL-1β, and IL-6 [28].…”

Section: Discussionmentioning

confidence: 99%

A double-blind, randomized trial on the effect of a broad-spectrum dietary supplement on key biomarkers of cellular aging in healthy adults

2016

J Clin Transl Res

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Background and Aim: Nutritional approaches that ameliorate cellular senescence may have the potential to counteract the effects of chronic disease. This study will investigate the effect of the Healthycell dietary supplement on markers of inflammation, oxidative stress, and DNA damage. Methods:Thirty adults between the ages of 18 and 55 were enrolled and randomly assigned to one of the two study conditions (n = 15 Healthycell and n = 15 placebo). Subjects participated in a four-week intervention and were assessed at baseline, four weeks, and six weeks (after a two-week washout period). Results Conclusions:Our findings show an improved inflammatory profile and decreased DNA damage. Additionally, the efficacy of Healthycell was primarily in older adults, where the processes that cause or are associated with cell senescence are more predominant.Relevance for patients: Healthycell may help to counteract the inflammatory effects of aging that lead to both cell senescence and the multitude of age-related chronic diseases. Keywords:dietary supplement DNA damage inflammation oxidative stress older adults senescence 136

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Novel phytonutrient contributors to antioxidant protection against cardiovascular disease

Cited by 68 publications

References 85 publications

Impact of ovariectomy, high fat diet, and lifestyle modifications on oxidative/antioxidative status in the rat liver

Impact of ovariectomy, high fat diet, and lifestyle modifications on oxidative/antioxidative status in the rat liver

Efficacy of a Solution Composed by Verbascoside, Polyvinylpyrrolidone (PVP) and Sodium Hyaluronate in the Treatment of Chemotherapy-induced Oral Mucositis in Children With Acute Lymphoblastic Leukemia

A double-blind, randomized trial on the effect of a broad-spectrum dietary supplement on key biomarkers of cellular aging in healthy adults

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