Novel photoplethysmography cardiovascular assessments in patients with Raynaud's phenomenon and systemic sclerosis: a pilot study

Abstract

Multisite PPG pulse technology showed potential diagnostic ability. By using measures of endothelial function, it differentiated SSc from control and PRP subjects with an accuracy of at least 81%. Objective pulse-derived measures of autonomic function and arterial disease in SSc have also been reported in this pilot study.

Innovative multi-site photoplethysmography measurement and analysis demonstrating increased arterial stiffness in paediatric heart transplant recipients

“…It is relatively low-cost and is quick to perform as pulses from multiple body sites can easily be acquired simultaneously. Our group has already A c c e p t e d M a n u s c r i p t 4 demonstrated various clinical applications using multi-site photoplethysmography (MPPG) pulse measurement technology and published data utilising pulse arrival timing measures from different peripheral body sites to assess cardiovascular ageing in normal adult populations [14][15][16][17], a pilot in heart transplant patients [18], peripheral arterial disease [19], chronic fatigue syndrome, [20] and cardiovascular function in systemic sclerosis [21]. The aim of this study was to assess arterial stiffness change in paediatric HTR in comparison with healthy children using MPPG technology.…”

Recent advances in the workup and management of Raynaud’s phenomenon

“…21 Magnification of ×200 is one of the most suitable options for everyday clinical It seems that the novel multisite photoplethysmography might be a practical and low -cost cardiovascular assessment tool for differentiating SSc from healthy controls and patients with primary RP by measuring endothelial function. 48 Endothelial and autonomic function as well as arterial disease were assessed using a pulse -wave analysis. 48 The identification of patients with RP and evaluation of their response to a cold stimulus over time by using photoacoustic imaging with a center frequency of 18 MHz and an optical wavelength range of 680 nm to 970 nm, which allowed to quantify tissue oxygenation levels, were also reported.…”

“…48 Endothelial and autonomic function as well as arterial disease were assessed using a pulse -wave analysis. 48 The identification of patients with RP and evaluation of their response to a cold stimulus over time by using photoacoustic imaging with a center frequency of 18 MHz and an optical wavelength range of 680 nm to 970 nm, which allowed to quantify tissue oxygenation levels, were also reported. 49 However, all these techniques are currently mainly available only in specialist centers and need further validation studies prior to their implementation in clinical practice.…”

“…48 A difference of more than 15 mm Hg between fingers or an absolute finger systolic blood pressure of less than 70 mm Hg may indicate occlusive disease. 48 The normal finger-brachial index may range from 0.8 to 1.3. Sphygmic wave amplitude is markedly lower in RP patients than in healthy controls.…”

“…Sphygmic wave amplitude is markedly lower in RP patients than in healthy controls. 48 Conventional angiography and magnetic resonance angiography provide anatomic information about the location and extension of the occlusive lesions and are used to assess peripheral of RP. A lower recovery rate and thermal gradient as well as a higher disparity in the nailfold temperature between the fingers at baseline and also after cold challenge were found in patients with SSc and may be useful for differentiating secondary RP from primary RP.…”