Novel phosphonate nucleoside as antiviral agents

Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting

“…Therefore, prodrug derivatives to mask the ionized phosphate group of nucleotides have been exploited,20, 21 but the approach can be limited due to rapid hydrolysis or dephosphorylation of the phosphate esters in vivo . Recent development of acyclic nucleoside analogues with a phosphonate bond has resulted in several successful antiviral prodrugs 22, 23. These phosphonates possess a phosphonate group attached to the acyclic nucleoside moiety through a stable PC bond, which is resistant to esterase hydrolysis.…”

Cu‐Catalyzed Asymmetric Allylic Alkylation of Phosphonates and Phosphine Oxides with Grignard Reagents

“…Optically active organophosphorus compounds are frequently encountered in many areas of chemistry, in particular medicinal chemistry1 and asymmetric catalysis 2. Within this class of compounds, chiral phosphonic acid, phosphonate, and phosphine oxide derivatives have attracted interest because of their interesting biological properties3 and synthetic versatility 4.…”

Nucleoside Analogs as Anti-HBV Agents

“…The nucleotides are converted to their diphosphates by pyrimidine or purine nucleoside monophosphate kinase and diphosphate kinase or by direct pyrophosphorylation [10][11][12][13]. Optionally, nucleotide can possibly be converted to their p-cholin, which functions as an intracellular reservoir of nucleotide as shown in the cidofovir case.…”