Novel Pharmacotherapies for B-Cell Lymphomas and Leukemias

Abstract

Novel pharmacotherapeutic agents were recently approved for treatment of low-grade B-cell neoplasms, and many other agents are under investigation. Several agents have demonstrated impressive activity in targeting malignant B-cell processes and specific pathways, all with the potential to expand our ability to effectively treat B-cell malignancies. The inhibitors of several cell regulatory proteins, including Bruton tyrosine kinase (Btk), phosphoinositide 3-kinase (PI3-K), B-cell lymphoma/leukemia-2 (Bcl-2), and histone deacetylases, as well as immunomodulatory agents are a few of the many pharmacotherapeutic agents under study. A comprehensive review and assessment is presented of the current pharmacotherapies under investigation targeting B-cell lymphomas and leukemias.

A Historical Tale of Two Lymphomas: Part II: Non-Hodgkin lymphoma

“…[32][33][34] More recently, radioimmunoconjugates, monoclonal antibodies against different antigens and molecule inhibitors, such as bruton tyrosine kinase inhibitors, have been added to the armamentarium of physicians treating NHL. 35 While the chances of a cure continue to improve with the advent of targeted therapy, parallel efforts are underway to reduce the short and long-term toxicity of these treatment options.…”