Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers

Du, Junbao; Dai, Jindong; Liu, Jun Long; Dankovich, Theresa A.

doi:10.1016/j.reactfunctpolym.2006.01.014

Cited by 92 publications

(42 citation statements)

References 44 publications

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“…Os tamanhos médios das esferas são menores do que os obtidos na complexação polieletrolítica de QT com carboximetil glucomananas (goma konjac) (1,2-1,6 mm) [38] . Na complexação de ácido hialurônico com QT, Vasiliu e colaboradores [39] obtiveram esferas de diâmetro médio de 0,72 a 1,15 mm dependendo da metodologia de preparação.…”

Section: Resultsunclassified

Efeito da modificação química na solubilidade e intumescimento de microesferas à base de goma do cajueiro carboximetilada e quitosana

et al. 2015

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ResumoEsferas de goma do cajueiro carboximetilada e quitosana foram produzidas via complexação polieletrolítica. As esferas foram modificadas quimicamente de modo a obter-se sistemas estáveis em meio ácido e que apresentassem uma resposta de intumescimento diferenciado frente à variação de pH. As esferas foram modificadas por reacetilação da quitosana e por reticulação com epicloridrina, glutaraldeído e genipina. As esferas reticuladas foram caracterizadas por meio de técnicas como: espectroscopia de absorção no infravermelho, análise termogravimétrica, microscopia eletrônica de varredura e quanto à solubilidade em pH 1,2 e ao intumescimento. As esferas de goma do cajueiro carboximetilada e quitosana reacetilada, e as esferas reticuladas com epicloridrina apresentaram baixa resistência à dissolução em pH 1,2. Entretanto, as esferas reticuladas com glutaraldeído e genipina apresentaram resistência à dissolução e baixo coeficiente de difusão. As esferas reticuladas com genipina apresentaram um grau de intumescimento maior do que as esferas reticuladas com glutaraldeído nas concentrações de 3% e 5% (massa/volume). As esferas reticuladas com genipina apresentaram intumescimento responsivo à variação de pH e estabilidade em pH 1,2, indicando que esses sistemas possuem potencial para uso em sistemas de liberação controlada de fármacos por via oral. PalavrasTchave: goma do cajueiro, carboximetilação, quitosana, reticulação. AbstractChitosan/carboxymethylated cashew gum beads were produced via polyelectrolytic complexation. The beads were chemically modified to achieve stable acidic medium and to provide a swelling response in different pH. The beads were modified by chitosan reacetylation and by crosslinking with epichlorohydrin, glutaraldehyde and genipin. The beads were characterized by techniques such as: infrared spectroscopy, thermogravimetry, scanning electron microscopy and regarding their solubility at pH 1.2 and swelling. The beads of carboxymethyl cashew gum and reacetylated chitosan and those crosslinked with epichlorohydrin had low resistances to dissolution at pH 1.2. However, the beads crosslinked with glutaraldehyde and genipin showed resistance to dissolution along with low diffusion coefficients. Moreover, beads crosslinked with genipin presented a higher degree of swelling than beads crosslinked with glutaraldehyde at concentrations of 3% and 5% (weight/volume). Beads crosslinked with genipin presented responsive behavior to pH variation and stability at pH 1.2, indicating that these systems have potential for use in controlled drug delivery systems for oral administration.

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Section: Resultsunclassified

Efeito da modificação química na solubilidade e intumescimento de microesferas à base de goma do cajueiro carboximetilada e quitosana

et al. 2015

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“…The beads swelled more rapidly in alkaline dissolution medium than in acidic medium, and this led to higher drug release in alkaline medium. In alkaline medium, probably a large swelling force was created by the electrostatic repulsion between the ionized acid groups (Du et al, 2006). An inverse relationship was observed between AlCl 3 concentration and the swelling ratio of the beads.…”

Section: Resultsmentioning

confidence: 99%

Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide

Maiti¹,

Dey²,

Banik³

et al. 2010

Drug Delivery

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“…Carboxymethyl derivatives of chitosan (CMC) were found to be nontoxic, anionic, and water soluble. Because of these excellent properties, CMC found applications in biomedical and environmental fields [14,[92][93][94][95]. Depending on the position of the carboxymethyl substitution, these derivatives can be classified as O-CMC, N-CMC, and N,O-CMC [14,93].…”

Section: 1 Carboxymethylationmentioning

confidence: 99%

Approaches for Functional Modification or Cross‐Linking of Chitosan

Anitha

Rejinold

Bumgardner

et al. 2012

Chitosan‐Based Systems for Biopharmaceuticals

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Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers

Cited by 92 publications

References 44 publications

Efeito da modificação química na solubilidade e intumescimento de microesferas à base de goma do cajueiro carboximetilada e quitosana

Efeito da modificação química na solubilidade e intumescimento de microesferas à base de goma do cajueiro carboximetilada e quitosana

Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide

Approaches for Functional Modification or Cross‐Linking of Chitosan

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