Novel pH-Responsive Amphiphilic Diblock Copolymers with Reversible Micellization Properties

Dai, Sheng; Ravi, Palaniswamy; Tam, Kam Chiu; Mao, B.W.; Gan, L. H.

doi:10.1021/la0340652

Cited by 112 publications

(145 citation statements)

References 15 publications

(22 reference statements)

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“…It is evident that between pH 5.4 and 8.8, the copolymer becomes insoluble due to complexation and overall charge neutralization near the isoelectric point (IEP) [28], [29]. This behavior is similar to that of P(MAA-b-DMAEMA) [29] and P(MAA-b-DEAEMA) [9] in solution. It can be concluded that the water-soluble C 60 containing P(MAA-b-DMAEMA) retains the polyampholyte properties in solution.…”

Section: Resultsmentioning

confidence: 77%

“…These compounds are usually either water-soluble groups such as alcohols [4], carboxylic acids [5], and amines [6], or long-chain hydrophilic polymers [7], [8]. These amphiphilic fullerene derivatives self-assemble into interesting nano-scale structures in water, which have a variety of potential applications [9]. For example, Sitharaman et al recently studied the aggregation properties of tris-malonic acid-C 60 (C 3 ) as a function of temperature, concentration and pH in aqueous solution.…”

Section: Introductionmentioning

confidence: 99%

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Self-Assembly of Stimuli-Responsive Water-Soluble [60]Fullerene End-Capped Ampholytic Block Copolymer

et al. 2005

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Section: Resultsmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Self-Assembly of Stimuli-Responsive Water-Soluble [60]Fullerene End-Capped Ampholytic Block Copolymer

et al. 2005

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“…Primary ester groups, present in the di-and tetrafunctional initiator, are stable in the adopted hydrolysis conditions. 39,40 The synthesis and the structure of the obtained polymers are sketched in Scheme 1. Details on synthesis and characterization are available as Supporting Information.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Polystyrene–Poly(sodium methacrylate) Amphiphilic Block Copolymers by ATRP: Effect of Structure, pH, and Ionic Strength on Rheology of Aqueous Solutions

et al. 2013

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“…Tam and coworkers [41] synthesized a pH-responsive Poly (Methacrylic Acid) -b-Poly ((2-Diethylamino) Ethyl Methacrylate) (PMAA-b-PDEAEMA) diblock copolymer via Atom Transfer Radical Polymerization (ATRP) technique using protected group chemistry of tert-butyl methacrylate, followed by hydrolysis under acidic conditions. This copolymer system is believed to have the potential for drug-delivery applications because of the biocompatibility of PMAA and PDEAEMA.…”

Section: Ph-responsive Amphiphilic Block Copolymersmentioning

confidence: 99%

Introduction of Polymer Nanoparticles for Drug Delivery Applications

Rempel¹

2015

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The essence of "nano-" science and technology is based on the finding that the properties of materials over the size range of 1-100 nm differ from those of the bulk material. The unique properties of these various types of intentionally produced nanomaterials provide them with novel electrical, catalytic, magnetic, mechanical, thermal, and imaging features that are highly desirable for applications in commercial, medical, military, and environmental sectors. These materials may also find their way into more complex nanostructures and systems. As new uses for materials with these special properties are identified, the number of products containing such nanomaterials and their possible applications continues to grow.In the fields of molecular biology and medicine, cancer has been the leading cause of death and a serious threat to the body health of *Corresponding author: Garry L Rempel, Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada; Tel: +1 5198884567, Extn: 32702; Fax: +1 5197464979; E-mail: grempel@uwaterloo.ca Citation: Wang H, Rempel GL (2015) Introduction of Polymer Nanoparticles for Drug Delivery Applications. J Nanotechnol Nanomed Nanobiotechnol 2: 008. human beings. Until now, the main techniques to fight cancer are non-targeted chemotherapy and radiation. However, it is unavoidable to prevent systematic side effects to the human body due to non-specific uptake by normal, healthy, noncancerous tissues because of the instinctive properties of the chemotherapy chemical agent featured with high toxicity and a lack of tumor specificity.In order to overcome the limitations of free chemotherapeutic agents, targeting of tumors with nanoparticulate drug carriers has received much attention and expectance [1,2]. Nanocarriers can offer many avenues over free drugs for the following aspects [3]: (1) protect the drug from premature degradation; (2) prevent drugs from prematurely interacting with the biological environment; (3) enhance absorption of the drugs into a selected tissue (for example, solid tumour); (4) control the pharmacokinetic and drug distribution profile; and (5) improve intracellular penetration.Let us first recall the important moments in the short but rapid development history of drug delivery systems (Figure 1). Lipid is the first nanotechnology based drug delivery system, which was discovered in the 1960s and later known as liposomes [4]. After that, biomaterials made of a variety of organic and inorganic substances were developed for drug delivery. In 1976, the first controlled release polymer drug delivery system was reported [5]. In 1980, pH stimuli drug delivery systems to trigger drug release [6] and cell specific targeting of liposomes were reported [7,8]. In 1987, the first long circulating liposome named "stealth liposomes" was described [9]. Subsequently, the use of Polyethylene Glycol (PEG) was known to increase circulation times for liposomes [10] and polymer nanoparticles [11] in 1990 and 1994, respe...

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Novel pH-Responsive Amphiphilic Diblock Copolymers with Reversible Micellization Properties

Cited by 112 publications

References 15 publications

Self-Assembly of Stimuli-Responsive Water-Soluble [60]Fullerene End-Capped Ampholytic Block Copolymer

Self-Assembly of Stimuli-Responsive Water-Soluble [60]Fullerene End-Capped Ampholytic Block Copolymer

Polystyrene–Poly(sodium methacrylate) Amphiphilic Block Copolymers by ATRP: Effect of Structure, pH, and Ionic Strength on Rheology of Aqueous Solutions

Introduction of Polymer Nanoparticles for Drug Delivery Applications

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