Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases

Abstract

Cryptotanshinone (CTS), a diterpenoid quinone, is found mostly in Salvia miltiorrhiza Bunge (S. miltiorrhiza) and plays a crucial role in many cellular processes, such as cell proliferation/self-renewal, differentiation and apoptosis. In particular, CTS’s profound physiological impact on various stem cell populations and their maintenance and fate determination could improve the efficiency and accuracy of stem cell therapy for high-incidence disease. However, as much promise CTS holds, these CTS-mediated processes are complex and multifactorial and many of the underlying mechanisms as well as their clinical significance for high-incidence diseases are not yet fully understood. This review aims to shed light on the impact and mechanisms of CTS on the actions of diverse stem cells and the involvement of CTS in the many processes of stem cell behavior and provide new insights for the application of CTS and stem cell therapy in treating high-incidence diseases.

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

“…Cryptotanshinone is a monomer with various pharmacological activities extracted from Salvia miltiorrhiza, which has various effects such as anticancer, anti‐inflammatory, anti‐oxidation, anti‐diabetes and anti‐obesity 233 . Cryptotanshinone comes from natural medicines and has the advantages of low toxicity and wide indications 233–235 . Yan et al.…”

“…233 Cryptotanshinone comes from natural medicines and has the advantages of low toxicity and wide indications. [233][234][235] Yan et al found that cryptotanshinone inhibits tumour growth by promoting ferroptosis in granulocytic myeloid-derived suppressor cells and TNBC cells through proteomics, single-cell transcriptome sequencing, ferroptosis phenotype detection, DARTS, microthermophoresis and molecular docking. 236…”