Novel Perspectives in Research on the Neural Crest and its Derivatives

Kalcheim, Chaya; Stanke, Matthias; Rohrer, Hermann; Jessen, Kristján R.; Mirsky, Rhona

doi:10.1002/9783527619689.ch12

Cited by 1 publication

(2 citation statements)

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“…Targeted deletion of single or multiple bHLH genes has revealed cascades that specify a given set of PNS neurons. For example, sympathetic neurons depend on the gene Achaete-Scute-like1 (Ascl1) for their initial formation, but require other genes for full differentiation [Kalcheim et al, 2006]. The origin of achaete-scute-like bHLH genes can be found in coelenterates [Seipel et al, 2004].…”

Section: Introductionmentioning

confidence: 99%

“…For example, Neurog1 regulates the expression of the bHLH gene NeuroD1 [Ma et al, 1998;Kalcheim et al, 2006] that regulates in turn the expression of the Pou domain factor Pou4f1 [Kim et al, 2001]. Pou4f1 is involved in the regulation of the expression of neurotrophin receptors such as trkB and trkC Kalcheim et al, 2006] that determine the survival of sensory neurons. Variable losses of sensory neurons have been reported in mice with targeted deletion of some of these genes Kim et al, 2001].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Analysis of Neurotrophin Receptors and Ligands in Vertebrate Neurons: Tools for Evolutionary Stability or Changes in Neural Circuits?

Bartheld

Fritzsch

2006

Brain Behav Evol

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To better understand the role of multiple neurotrophin ligands and their receptors in vertebrate brain evolution, we examined the distribution of trk neurotrophin receptors in representatives of several vertebrate classes. Trk receptors are largely expressed in homologous neuronal populations among different species/classes of vertebrates. In many neurons, trkB and trkC receptors are co-expressed. TrkB and trkC receptors are primarily found in neurons with more restricted, specialized dendritic and axonal fields that are thought to be involved in discriminative or ‘analytical’ functions. The neurotrophin receptor trkA is expressed predominantly in neurons with larger, overlapping dendritic fields with more heterogeneous connections (‘integrative’ or ‘modulatory’ systems) such as nociceptive and sympathetic autonomic nervous system, locus coeruleus and cholinergic basal forebrain. Surveys of trk receptor expression and function in the peripheral nervous system of different vertebrate classes reveal trends ranging from dependency on a single neurotrophin to a more complex dependency on increasing numbers of neurotrophins and their receptors, for example, in taste and inner ear innervation. Gene deletion studies in mice provide evidence for a complex regulation of neuronal survival of sensory ganglion cells by different neurotrophins. Although expression of neurotrophins and their receptors is predominantly conserved in most circuits, increasing diversity of neurotrophin ligands and their receptors and a more complex dependency of neurons on neurotrophins might have facilitated the formation of at least some new neuronal entities.

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Section: Introductionmentioning

confidence: 99%