Novel perfluoroalkylated oligo(oxyethylene) methyl ethers with high hemocompatibility and excellent co-emulsifying properties for potential biomedical uses

Selected physicochemical aspects of poly- and perfluoroalkylated substances relevant to performance, environment and sustainability—Part one

“…Nonionic surfactants with a poly(ethylene glycol) (PEG) hydrophilic chain (e.g., ACH 2 CH 2 (CH 2 CH 2 O) n H), a sugar function (e.g. glucose, saccharose) or a polyol can easily be derived from telomer alcohols (Riess and Greiner, 2000;Kaplánek et al, 2009).…”

Strategies for synthesizing non-bioaccumulable alternatives to PFOA and PFOS

“…Besides, fluorinated surfactants usually have high thermal and chemical stability [1][2][3]. They are usually composed of a perfluorinated chain and a hydrophilic group [4][5][6]. The most known fluorinated surfactants are PFOA (C 7 F 15 CO 2 H), APFO (ammonium perfluorooctanoate) and PFOS (C 8 F 17 SO 3 X, with X = K, Na, H).…”

Highly fluorinated amphiphilic molecules and self-assemblies with biomedical potential

“…Two series of F-alkylated derivatives of mono-, di-and tri (oxyethylene) glycols, C n F 2n + 1 CH 2 CHOHCH 2 (OCH 2 CH 2 ) p OCH 3 and C n F 2n + 1 CH 2 CH 2 HCH 2 (OCH 2 CH 2 ) p OCH 3 (n = 6, 8, 10; p = 1-3), have been prepared that showed low hemolytic activity and good coemulsifying properties for F-decalin/Pluronic F68 emulsions [28]. All the above studies have confirmed the beneficial effect of F-alkyl groups in reducing hemolysis and acute toxicity.…”