The major technique of an air-defense warhead is to improve the damage after effect. Therefore, a new Kinetic Energy Rod (KER) warhead named profiled rod warhead is proposed in this paper. The detonation process is simulated by ANSYS/LS-DYNA, and the deployment velocity and initial flight attitude of rod are achieved. Rigid body dynamics equations of rod, which accounts for the influence of air resistance, are set up to predict the flight trajectory of long-distance. The results show that profiled rods are conducted to determine a higher penetrability compared with traditional cylindrical rods, and the profiled rods may provide a better penetration angle that still maintains a significant penetrability against projectiles when the rods move off long-distance range.