Novel PEG-organized biocompatible fluorescent nanoparticles doped with an ytterbium cyanoporphyrazine complex for biophotonic applications

Klapshina, Larisa G.; Douglas, William E.; Grigoryev, Ilya S.; Ladilina, E. Yu.; Shirmanova, Marina V.; Mysyagin, Sergey; Balalaeva, Irina V.; Zagaynova, Elena V.

doi:10.1039/c0cc02842h

Cited by 22 publications

(9 citation statements)

References 10 publications

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“…There is a variety of intensively studied drug carrying vehicles which can be designed with synthetic (polyethylene glycol, polylactic and polyglycolic acids, polycaprolactone, derivatives of polymethacrilic acid, etc.) [78,79,80,81,82,83] or natural polymers (gelatin, collagen, chitosan, dextran, solid lipid nanoparticles, etc.) [84,85,86,87].…”

Section: Passive Targetingmentioning

confidence: 99%

Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency

Kutova

Guryev

Соколова

et al. 2019

Cancers

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Malignant tumors are characterized by structural and molecular peculiarities providing a possibility to directionally deliver antitumor drugs with minimal impact on healthy tissues and reduced side effects. Newly formed blood vessels in malignant lesions exhibit chaotic growth, disordered structure, irregular shape and diameter, protrusions, and blind ends, resulting in immature vasculature; the newly formed lymphatic vessels also have aberrant structure. Structural features of the tumor vasculature determine relatively easy penetration of large molecules as well as nanometer-sized particles through a blood–tissue barrier and their accumulation in a tumor tissue. Also, malignant cells have altered molecular profile due to significant changes in tumor cell metabolism at every level from the genome to metabolome. Recently, the tumor interaction with cells of immune system becomes the focus of particular attention, that among others findings resulted in extensive study of cells with preferential tropism to tumor. In this review we summarize the information on the diversity of currently existing approaches to targeted drug delivery to tumor, including (i) passive targeting based on the specific features of tumor vasculature, (ii) active targeting which implies a specific binding of the antitumor agent with its molecular target, and (iii) cell-mediated tumor targeting.

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Section: Passive Targetingmentioning

confidence: 99%

Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency

Kutova

Guryev

Соколова

et al. 2019

Cancers

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“…50 Pre-treated ultraclean gold electrodes were then dried in a flow of nitrogen gas and immediately immersed in a 10 mM solution of HS-C 11 -(EG) 3 -OCH 2 -COOH in ethanol for 16 hours at room temperature for self-assembly. The biocompatible 51,52 and antifouling properties 53,54 of such PEG containing films are expected to enable specific assessments to be made in complex biological fluid. After the formation of self-assembled monolayer, gold surfaces were rinsed with ethanol then water and dried in a flow of nitrogen gas prior to incubation in a solution containing 0.4 M EDC and 0.1 M NHS for 15 minutes (terminal carboxyl group activation) and then 10 mM alpha-synuclein solution (0.1 M acetate buffer, pH 4) for 1 hour (Fig.…”

Section: Surface Modificationmentioning

confidence: 99%

The robust electrochemical detection of a Parkinson's disease marker in whole blood sera

Bryan¹,

Liu²,

Forsgren³

et al. 2012

Chem. Sci.

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“…In aqueous media PEG forms macromolecular aggregates that contain GNPs. Such a strategy was used for the preparation of a biocompatible ytterbium cyanoporphyrazine complex [29]. Molecules of PF127 did not attach to GNPs surface.…”

Section: Discussionmentioning

confidence: 99%

Selection of stabilizing agents to provide effective penetration of gold nanoparticles into cells

Elagin

Сергеева

Bugrova

et al. 2014

Photonics &Amp; Lasers in Medicine

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Objective: Gold nanorods are known to be promising agents for photothermal therapy. But the uptake of rodshaped nanoparticles is lower than their spherical counterpart. It was therefore the objective of this study to select gold nanoparticles (GNPs)-stabilizing agents in order to provide effective penetration into cancer cells. Materials and methods:The work was carried out on human ovarian adenocarcinoma SKOV-3 cells. The gold nanorods used in this work had a plasmon resonance peak at 800 nm. The nanoparticles were stabilized by Pluronic ® F-127 (PF127), chitosan or polyethylene glycol (PEG); the latter with 6000 Da and 40,000 Da molecular weight. Penetration and intracellular distribution of GNPs were investigated by transmission electron microscopy (TEM) and two-photon luminescence microscopy (2PLM) techniques. Results: By means of 2PLM and TEM, it could be shown that PF127 facilitates cellular uptake of GNPs very effectively. PF127-stabilized GNPs rapidly (by 1.5 h) penetrated the cell membrane and into the cytoplasm and cell nucleus. GNPs stabilized by chitosan were slowly internalized by the cells in smaller amount. GNPs stabilized by PEG with different molecular weights had difficulty to penetrate into the cells -GNPs were localized on the outer side of the cell membrane after short incubation, and single agglomerates were found in the cells after an extended incubation time. Conclusion: Nanoparticles stabilized with PF127 were the most effective nanoparticles to penetrate into the cells and were located in the cytoplasm and cell nuclei. Nanoparticles stabilized with chitosan were internalized into cells at a slower rate and in smaller amounts than those stabilized with PF127. Nanoparticles stabilized with PEG 6000 Da and PEG 40,000 Da were located mainly on cell membranes and could be found in the cytoplasm only after a longer incubation time.

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Novel PEG-organized biocompatible fluorescent nanoparticles doped with an ytterbium cyanoporphyrazine complex for biophotonic applications

Cited by 22 publications

References 10 publications

Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency

Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency

The robust electrochemical detection of a Parkinson's disease marker in whole blood sera

Selection of stabilizing agents to provide effective penetration of gold nanoparticles into cells

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