Novel Paravascular Lesions with Abnormal Autofluorescence in Pathologic Myopia

Fang, Yuxin; Ishida, Tomoka; Du, Ran; Xie, Shiqi; Igarashi-Yokoi, Tae; Yoshida, Takeshi; Watanabe, Takashi; Onishi, Yuka; Ohno‐Matsui, Kyoko

doi:10.1016/j.ophtha.2020.07.044

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…At present, OCT is the method commonly used to examinate the fundus. Thus, an understanding of the relationship between OCT performance, indicators, and vision will not only further develop the clinical value of this examination method but will also help to accurately evaluate the vision of patients ( 16 , 17 ). This working group carried out this study to extend understandings of this relationship.…”

Section: Discussionmentioning

confidence: 99%

A retrospective analysis on comparison of optical coherence tomography manifestations among AMD, CEC, PM and ICN and its relationship with vision

Chen¹,

Li²

2022

Ann Transl Med

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Background: Both macular choroidal neovascularization (MCN) and visual changes can occur in agerelated macular degeneration (AMD), central exudative chorioretinopathy (CEC), pathological myopia (PM) and idiopathic choroidal neovascularization (ICN), but whether the optical coherence tomography (OCT) manifestations of the four diseases are different and their relationships with vision are not clear. This study clarifies this problem and can guide clinicians to prevent vision changes of patients according to OCT performance. Methods: 76 patients with MCN, included 25 AMD, 21 CEC, 18 PM and 12 ICN [refer to Chinese Ophthalmology (3rd Edition)], detected by OCT instrument, were enrolled in this study from June 2020 to June 2022. The OCT manifestations and indexes were observed. A comprehensive refractometer was used for detection of best corrected visual acuity (BCVA) and axial length (AL). Pearson chi squared and 1 way analysis of variance were used for enumeration data and continuous data test, and Pearson correlation coefficient was used for relationship analysis.Results: (I) Macular edema proportions in the MCN eyes among AMD, CEC, PM and ICN groups were 96.00% and 94.12%, 14.29% and 14.29%, 44.44% and 32.00%, 33.33% and 28.57%, with statistical differences (both P<0.001). (II) Patients with macular edema had a significantly higher loose and thickened tissue reflex of the neuroepithelial layer (100.00% vs. 4.26%) and limited non-reflective dark area (100.00% vs. 4.26%) (both P<0.001). (III) PM had the lowest width, height and central fovea thickness (CFT) [(1,403.43±114.41), (210.74±21.22) and ( 250.70±41.36) μm], and the highest distance to the fovea, BCVA and AL [(234.44±288.69) μm, (0.30±0.08) Log minimal angle of resolution (MAR), (28.48±5.72) mm] (all P<0.001). (IV) The width and height of patients with macular edema were lower than those of patients without macular edema [(1,738.43±348.71) vs. (2,493.95±771.53) μm, P<0.001; (305.71±81.22) vs. (367.29±107.91) μm, P=0.002] (P<0.05). (V) The width and height, CFT were negatively correlated to BCVA (r=−0.635, −0.712, −0.724, all P<0.001), and height, CFT were negatively correlated to AL (r=−0.244, −0.275, P=0.018, 0.007). The distance to the fovea was positively correlated to BCVA and AL (r=0.241, P=0.019; r=0.267, P=0.007).Conclusions: Most of the OCT indexes were related to the BCVA and AL in MCN patients, and MCN patients with OCT changes should be reminded to protect their vision.

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Section: Discussionmentioning

confidence: 99%

A retrospective analysis on comparison of optical coherence tomography manifestations among AMD, CEC, PM and ICN and its relationship with vision

Chen¹,

Li²

2022

Ann Transl Med

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Genome‐Wide Association Analysis Identifies LILRB2 Gene for Pathological Myopia

Jiang,

Huang,

Dai

et al. 2024

Advanced Science

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Pathological myopia (PM) is one of the leading causes of blindness, especially in Asia. To identify the genetic risk factors of PM, a two‐stage genome‐wide association study (GWAS) and replication analysis in East Asian populations is conducted. The analysis identified LILRB2 in 19q13.42 as a new candidate locus for PM. The increased protein expression of LILRB2/Pirb (mouse orthologous protein) in PM patients and myopia mouse models is validated. It is further revealed that the increase in LILRB2/Pirb promoted fatty acid synthesis and lipid accumulation, leading to the destruction of choroidal function and the development of PM. This study revealed the association between LILRB2 and PM, uncovering the molecular mechanism of lipid metabolism disorders leading to the pathogenesis of PM due to LILRB2 upregulation.

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Intraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopia

Yoshida,

Yoshimoto,

Nomura

et al. 2023

Sci Rep

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The aim is to study the intraocular pressure (IOP)-lowering effects of additional administration of ripasudil in open-angle glaucoma (OAG) patients including high myopia (HM) and pathological myopia (PM). Study design is retrospective cohort study. We assessed the changes in the mean IOP between the HM eyes (axial length ≧ 26.5 mm 33 eyes) and the non-HM eyes (axial length < 26.5 mm 29 eyes) at 4 and 12 weeks from baseline. We also assessed the IOP changes between the PM eyes (21 eyes) and the non-PM eyes (41 eyes). The significant IOP reduction by the ripasudil administration was observed at 4 weeks in the non-HM eyes and at 12 weeks in HM and non-HM eyes. And the IOP reduction in the HM eyes was significantly less than the non-HM eyes at 4 and 12 weeks. IOP reduction by ripasudil had statistically significant association with the baseline IOP and presence of PM. Furthermore, significant IOP reduction by the ripasudil administration was observed at 4 and 12 weeks in the non-PM eyes, but not in the PM eyes. The additional administration of ripasudil was effective in the HM eyes, but less than non-HM eyes. And the PM may negatively contribute to reducing the IOP by ripasudil.

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Novel Paravascular Lesions with Abnormal Autofluorescence in Pathologic Myopia

Cited by 3 publications

References 6 publications

A retrospective analysis on comparison of optical coherence tomography manifestations among AMD, CEC, PM and ICN and its relationship with vision

A retrospective analysis on comparison of optical coherence tomography manifestations among AMD, CEC, PM and ICN and its relationship with vision

Genome‐Wide Association Analysis Identifies LILRB2 Gene for Pathological Myopia

Intraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopia

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