Novel palladium(II) complexes of N-(5-nitro-salicylidene)-Schiff bases: Synthesis, spectroscopic characterization and cytotoxicity investigation

Özdemir, Özlem; Gürkan, Perihan; Demir, Yaprak Dilber Şimay; Ark, Mustafa

doi:10.1016/j.molstruc.2020.127852

Cited by 16 publications

(6 citation statements)

References 46 publications

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“… 18 - 21 All of the complexes tested exhibited antitumor activity, however, C5 and C6 had the lower IG50 which may be attributed, at least in part, to both the structure and substituent which is involved in the mechanism of ligand exchange in square-planar Pd and Pt compounds and it is very important for the stability of the Pd(II) complex in the biological media. 31 Pd(II) complexes derived from Schiff base ligands with different chemical structures from ours also exhibited cytotoxic effects towards MCF-7 32 - 36 and MDA-MB-435 37 , 38 cells, highlighting the importance of Pd(II) substituent and donors for complexes activities.…”

Section: Resultsmentioning

confidence: 54%

“…[18][19][20][21] All of the complexes tested exhibited antitumor activity, however, C5 and C6 had the lower IG50 which may be attributed, at least in part, to both the structure and substituent which is involved in the mechanism of ligand exchange in square-planar Pd and Pt compounds and it is very important for the stability of the Pd(II) complex in the biological media. 31 Pd(II) complexes derived from Schiff base ligands with different chemical structures from ours also exhibited cytotoxic effects towards MCF-7 [32][33][34][35][36] and MDA-MB-435 37,38 cells, highlighting the importance of Pd(II) substituent and donors for complexes activities. One interesting feature of our series of compounds was its capacity to reach maximum inhibition of growth values around 80%, against apoptosis-resistant MDA-MB-435 cells, demonstrated by the short term growth inhibition analysis that was further confirmed by the clonogenic assay.…”

Section: Accepted Manuscriptmentioning

confidence: 56%

“…Cell morphology alterations, suggesting cell death induction, were also observed upon palladium(II) complexes, with Schiff bases derived from diverse ligands, treatment. 18,21,36,38 DNA cleavage Pd(II) complexes treatment induced both cell DNA fragmentation and plasmid DNA cleavage (Fig. 5).…”

Section: Morphological and Morphometrics Alterations And Cell Deathmentioning

confidence: 95%

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Cytotoxicity Induced by Newly Synthesized Palladium (II) Complexes Lead to the Death of MCF-7 and MDA-MB-435 Cancer Cell Lines

et al. 2021

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Purpose: Breast cancer is the most common female malignancy and melanoma is the most lethal type of skin cancer. Traditional therapy for cancer treatment is far from satisfactory due to drug resistance and side effects, thus a search for new medicines is being emphasized. Palladium(II) complexes have been reported as anticancer potential agents. In this work, the anticancer activities and cell death induction of a new series of square-planar palladium(II) complexes were evaluated against MCF-7 and MDA-MB-435 cancer cells. Methods: MCF-7 (breast carcinoma) and MDA-MB-435 (melanoma) cells were cultivated, and treated with ligand and Pd(II) complexes. Cell growth, migration and adhesion inhibition, morphological alterations, cell death induction and, DNA interaction upon treatment were studied. Results: Pd(II) complexes exhibited both short and long-term antiproliferative effects on both cell lines, reducing by 80% cell growth in the SRB assay and abolishing long-term proliferation, estimated by the clonogenic assay. Complexes reduced significantly (p < 0.05) cell migration and adhesion when compared to the control group. Complexes induced morphological alterations in cell lines and significant (p<0.05) cellular shrinkage. Cell death was induced and the complexes were able to interact with DNA, inducing cleavage of double-stranded DNA, which may account for the complexes cytotoxic effects, observed against both MCF-7 and MDA-MB-435 cells. Conclusion: Overall, the complexes exhibited cytotoxic activities and induced cell death. These observations emphasize an anticancer role with a potential therapeutic value for Pd(II) complexes to improve the outcome of patients with breast cancer and melanoma.

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Section: Resultsmentioning

confidence: 54%

Section: Accepted Manuscriptmentioning

confidence: 56%

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Cytotoxicity Induced by Newly Synthesized Palladium (II) Complexes Lead to the Death of MCF-7 and MDA-MB-435 Cancer Cell Lines

et al. 2021

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“…According to literature survey, it could be noted that: i. Antitumor activity of the compounds is dependent on both structure and dose [48]. ii.…”

Section: Figure 7 Phase Contrast Photographs Of Hek-293 Cells At 48 Hours (X200)mentioning

confidence: 99%

Antioxidant and Cytotoxic Activity Studies in Series of Higher Amino Acid Schiff Bases

Özdemir

Gürkan

Demir

et al. 2020

Gazi University Journal of Science

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“…Several studies describing the phosphorescent properties of hydrazone Pd(II) complexes have been reported in the scientific literature, 55 and they continue to attract considerable attention due to their widespread applications in catalytic processes 68 and organic syntheses 69 and for their industrial 70 and biological 71,72 relevance. From the perspective of coordination chemistry, the isonicotinhydrazone ligand, HL 1 , typically coordinates transition metal ions via two different donor sets, in a tridentate manner as a N 2 O donor, and from the N atom of the 4-pyridyl substituent, facilitating the assembly of polynuclear 1-D chains such as the previously reported Cu(II) complex [Cu 4 (L 1 ) 2 (μ-OAc) 2 (μ-OAc) 4 ] n (see Figure 1).…”

Section: ■ Introductionmentioning

confidence: 99%

Synthesis, Study, and Application of Pd(II) Hydrazone Complexes as the Emissive Components of Single-Layer Light-Emitting Electrochemical Cells

et al. 2021

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For the first time, square planar Pd(II) complexes of hydrazone ligands have been investigated as the emissive components of light-emitting electrochemical cells (LECs). The neutral transition metal complex, [Pd(L1)2]·2CH3OH (1), (HL1 = (E)-N′-(phenyl(pyridin-2-yl)methylene)isonicotinhydrazide), was prepared and structurally characterized. Complex 1 displays quasireversible redox properties and is emissive at room temperature in solution with a λmax of 590 nm. As a result, it was subsequently employed as the emissive material of a single-layer LEC with configuration FTO/1/Ga/In, where studies reveal that it has a yellow color with CIE(x, y) = (0.33, 0.55), a luminance of 134 cd cm–2, and a turn-on voltage of 3.5 V. Protonation of the pendant pyridine nitrogen atoms of L1 afforded a second ionic complex [Pd(L1H)2](ClO4)2 (2) which is also emissive at room temperature with a λmax of 611 nm, resulting in an orange LEC with CIE(x, y) = (0.43, 0.53). The presence of mobile anions and cations in the second inorganic transition metal complex resulted in more efficient charge injection and transport which significantly improved the luminance and turn-on voltage of the device to 188.6 cd cm–2 and 3 V, respectively. This study establishes Pd(II) hydrazone complexes as a new class of materials whose emissive properties can be chemically tuned and provides proof-of-concept for their use in LECs, opening up exciting new avenues for potential applications in the field of solid state lighting.

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Novel palladium(II) complexes of N-(5-nitro-salicylidene)-Schiff bases: Synthesis, spectroscopic characterization and cytotoxicity investigation

Cited by 16 publications

References 46 publications

Cytotoxicity Induced by Newly Synthesized Palladium (II) Complexes Lead to the Death of MCF-7 and MDA-MB-435 Cancer Cell Lines

Cytotoxicity Induced by Newly Synthesized Palladium (II) Complexes Lead to the Death of MCF-7 and MDA-MB-435 Cancer Cell Lines

Antioxidant and Cytotoxic Activity Studies in Series of Higher Amino Acid Schiff Bases

Synthesis, Study, and Application of Pd(II) Hydrazone Complexes as the Emissive Components of Single-Layer Light-Emitting Electrochemical Cells

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