Novel oxytocin receptor antagonists for tocolysis: a systematic review and meta-analysis of the available data on the efficacy, safety, and tolerability of retosiban

Marchand, Greg; Blumrick, Richard; Ruuska, Alexandra; Ware, Kelly; Masoud, Ahmed Taher; King, Alexa; Ruther, Stacy; Brazil, Giovanna; Cieminski, Kaitlynne; Calteux, N.; Ulibarri, Hollie; Sainz, Katelyn

doi:10.1080/03007995.2021.1944076

Cited by 9 publications

(2 citation statements)

References 54 publications

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“…To counter this issue, non-peptides with high oxytocin receptor selectivity such as retosiban are being investigated (Thornton et al 2017). Three clinical trials assessing retosiban in the management of preterm birth were evaluated in a systematic review but did not show a significant advantage in prolonging pregnancies compared to placebo (Marchand et al 2021). However, the favourable safety profile with minimal maternal and fetal adverse effects support further research into this class of drugs.…”

Section: Oxytocin Receptor Antagonistsmentioning

confidence: 99%

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth

et al. 2023

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Preterm birth is the leading cause of neonatal morbidity and mortality globally. Despite extensive research into the underlying pathophysiology, rates of preterm birth have not significantly reduced. Currently, preterm labour management is based on optimising neonatal outcomes. Treatment involves administering drugs (tocolytics) to suppress uterine contractions to allow sufficient time for transfer to an appropriate facility and administration of antenatal corticosteroids for fetal lung maturation. Current tocolytics are limited as they are associated with adverse maternal and fetal effects and only delay delivery for a short period. There has been a serious lack of therapeutic development for preterm birth, and new approaches to protect against or delay preterm birth are urgently needed. Repurposing drugs for prevention of preterm birth presents as a promising approach by reducing the time and costs associated with pharmaceutical drug development. In this review, we explore the evidence for the potential of therapies, specifically proton pump inhibitors, tumor necrosis factor inhibitors, prostaglandin receptor antagonists, aspirin, and statins, to be repurposed as preventatives and/or treatments for preterm birth. Importantly, many of these innovative approaches being explored have good safety profiles in pregnancy. We also review how delivery of these drugs can be enhanced, either through targeted delivery systems or via combination therapy approaches. We aim to present innovative strategies capable of targeting multiple aspects of the complex pathophysiology that underlie preterm birth. There is an urgent unmet need for preterm birth therapeutic development and these strategies hold great promise for improving neonatal outcomes.

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Section: Oxytocin Receptor Antagonistsmentioning

confidence: 99%

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth

et al. 2023

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“…A qualidade dos estudos variou entre baixa e alta.3.2.5 Atualizações para tocólise em TPPSomente o estudode Marchand et al (2021) avaliou a tocólise para o tratamento de TPP. Os autores incluíram três ensaios com um total de 116 pacientes para avaliar a eficácia, segurança e tolerabilidade do retosiban -um novo tocolítico ainda pouco disponível -no tratamento do trabalho de parto prematuro Marchand et al (2021). verificaram que não houve diferenças significativas entre retosiban e placebo em nascimentos pré-O nascimento prematuro é uma preocupação global de saúde e continua a contribuir para um substancial morbidade e mortalidade neonatal, apesar dos avanços nos cuidados obstétricos e neonatais.…”

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Linfoma De Grandes Células B Com Acometimento Gastrointestinal: Evolução Endoscópica Após Início Do Tratamento

Mendes¹,

Babani²,

Macedo³

et al. 2022

Medicina: Campo Teórico, Métodos E Geração De Conhecimento 3

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Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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A historical narrative review through the field of tocolysis in threatened preterm birth

van Winden,

Roos,

Mol

et al. 2024

European Journal of Obstetrics & Gynecology and Reproductiv

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Novel oxytocin receptor antagonists for tocolysis: a systematic review and meta-analysis of the available data on the efficacy, safety, and tolerability of retosiban

Cited by 9 publications

References 54 publications

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth

Linfoma De Grandes Células B Com Acometimento Gastrointestinal: Evolução Endoscópica Após Início Do Tratamento

A historical narrative review through the field of tocolysis in threatened preterm birth

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